2-{[(5-t-butylisoxazol-3-yl)imino]methyl}-phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-{[(5-t-butylisoxazol-3-yl)imino]methyl}-phenol
• 英文别名: 2-{[(5-Tert-butyl-3-isoxazolyl)imino]methyl}phenol；2-[(5-tert-butyl-1,2-oxazol-3-yl)iminomethyl]phenol
• 化学式: C₁₄H₁₆N₂O₂
• 分子量: 244.293
• InChiKey: ABAJNCPPJKWNAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基-5-叔丁基异唑 、 邻甲基苄醇 反应 0.07h， 以96%的产率得到2-{[(5-t-butylisoxazol-3-yl)imino]methyl}-phenol
  参考文献：
  名称：

  SOLVENT-FREE SYNTHESES OF SALICYLALDIMINES ASSISTED BY MICROWAVE IRRADIATION

  摘要：

  A microwave-assisted condensation of salicylaldehyde and aryl amines without solvent were efficiently performed to form a series of salicylaldimines in high yields, which were confirmed by IR, H-1 NMR, C-13 NMR and elemental analyses. The microwave-assisted condensation provided a convenient environmental-friendship methodology for syntheses of Schiff-base in organic syntheses.

  DOI：

  10.1081/scc-120006012

文献信息

• SOLVENT-FREE SYNTHESES OF SALICYLALDIMINES ASSISTED BY MICROWAVE IRRADIATION
  作者：Haijian Yang、Wen-Hua Sun、Zilong Li、Leyong Wang

  DOI：10.1081/scc-120006012

  日期：2002.1

  A microwave-assisted condensation of salicylaldehyde and aryl amines without solvent were efficiently performed to form a series of salicylaldimines in high yields, which were confirmed by IR, H-1 NMR, C-13 NMR and elemental analyses. The microwave-assisted condensation provided a convenient environmental-friendship methodology for syntheses of Schiff-base in organic syntheses.