Monoaryl- and Bisaryldihydroxytropolones as Potent Inhibitors of Inositol Monophosphatase
作者:Serge R. Piettre、Catherine André,、Marie-Christine Chanal、Jean-Bernard Ducep、Brigitte Lesur、François Piriou、Pierre Raboisson、Jean-Michel Rondeau、Charles Schelcher、Pascale Zimmermann、Axel J. Ganzhorn
DOI:10.1021/jm9701942
日期:1997.12.1
The first successful preparation of mono- and disubstituted 3,7-dihydroxytropolone involves a four-step synthetic scheme. Thus, bromination of 3,7-dihydroxytropolone (8) followed by permethylation of the resultant products furnished gram quantities of intermediates 13-18. Single or double Suzuki coupling reactions between these permethylated monobromo- and dibromodihydroxytropolone derivatives and