2-(5-morpholino-1,3,4-thiadiazol-2-yl)aniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(5-morpholino-1,3,4-thiadiazol-2-yl)aniline
• 英文别名: 2-(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)aniline
• 化学式: C₁₂H₁₄N₄OS
• 分子量: 262.335
• InChiKey: AHZVPHWPACFZNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-氨基-4(3H)-喹唑啉酮 在 sodium hydroxide 、 硫酸 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2-(5-morpholino-1,3,4-thiadiazol-2-yl)aniline
  参考文献：
  名称：

  Thioureidoquinazolin-4(3H)-ones

  摘要：

  3-(N',N'-Dialkylthioureido)quinazolin-4( prepared by the reaction of 3-aminoquinazolin-4(3H)-one with thiuram disulfides undergo the previously unknown acid-induced recyclization to give the corresponding 5-(2-aminophenyl)-2-dialkylamino-1,3,4-thiadiazoles. The structures of the products obtained were confirmed by IR and H-1 and C-13 NMR data. A plausible mechanism of the recyclization is discussed.

  DOI：

  10.1007/bf02496350

文献信息

• [EN] AMIDE DERIVATIVES AS SIRTUIN MODULATORS<br/>[FR] DÉRIVÉS D'AMIDE COMME MODULATEURS DE SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009058348A1

  公开（公告）日：2009-05-07

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

  提供的是由结构公式（I）表示的新的sirtuin调节化合物及其用途。sirtuin调节化合物可用于延长细胞寿命，以及治疗和/或预防多种疾病和紊乱，例如与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红相关的疾病或紊乱，以及将从增加线粒体活性中受益的疾病或紊乱。还提供了包含sirtuin调节化合物与另一种治疗剂的组合的药物组合物。
• AMIDE DERIVATIVES AS SIRTUIN MODULATORS
  申请人：Oalmann Christopher

  公开号：US20110039847A1

  公开（公告）日：2011-02-17

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了由结构式（I）所代表的新型sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，并治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝固障碍、炎症、癌症和/或潮红症，以及需要增加线粒体活性的疾病或障碍。此外，还提供了含有sirtuin调节化合物与另一种治疗剂的组合物。
• Thioureidoquinazolin-4(3H)-ones
  作者：G. G. Rusu、N. A. Barba、M. Z. Krimer

  DOI：10.1007/bf02496350

  日期：2000.10

  3-(N',N'-Dialkylthioureido)quinazolin-4( prepared by the reaction of 3-aminoquinazolin-4(3H)-one with thiuram disulfides undergo the previously unknown acid-induced recyclization to give the corresponding 5-(2-aminophenyl)-2-dialkylamino-1,3,4-thiadiazoles. The structures of the products obtained were confirmed by IR and H-1 and C-13 NMR data. A plausible mechanism of the recyclization is discussed.