三氟甲哌丙嗪二马来酸 | 605-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 三氟甲哌丙嗪二马来酸
• 中文别名: 三氟拉嗪二马来酸盐
• 英文名称: (Z)-but-2-enedioic acid;10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
• CAS: 605-75-4
• 化学式: C25H28F3N3O4S
• 分子量: 523.6
• InChiKey: UQFOQSMOXMXVDH-BTJKTKAUSA-N

物化性质

• 稳定性/保质期：

  性质与稳定性：在常温常压下，该物质不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  4.66
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• METHOD FOR TREATING/PREVENTING DISEASE USING COGNITIVE ABILITY OF CEREBRUM AND PHARMACEUTICAL
  申请人：Minowada Takuro

  公开号：US20110092548A1

  公开（公告）日：2011-04-21

  An object of the present invention is to develop a method of enhancing the cognitive ability of a brain to fundamentally cure a disease. It has been found out that, by using a medicament for treating or preventing a disease including a combination of a major tranquilizer, and vitamin C or a salt thereof and, if necessary, drip infusion, an antidepressant and an iron agent, the cognitive ability of a brain is enhanced, thus, an arbitrary disease including various cancers can be treated. The present invention also provides a method for treating or preventing a disease including a step of administering a major tranquilizer, and vitamin C or a salt thereof to a subject suffering from the disease.

  本发明的目的是开发一种增强大脑认知能力的方法，从根本上治愈疾病。研究发现，通过使用治疗或预防疾病的药物，包括主要的镇静剂、维生素C或其盐以及必要时的滴注输液、抗抑郁剂和铁剂的组合，可以增强大脑的认知能力，从而治疗包括各种癌症在内的任何疾病。本发明还提供了一种治疗或预防疾病的方法，包括给患有该疾病的受试者注射主要的镇静剂、维生素C或其盐的步骤。
• METHOD FOR PRODUCING PATCH, AND PATCH
  申请人：Hashimoto Eiji

  公开号：US20140037710A1

  公开（公告）日：2014-02-06

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug:the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产贴片的方法，包括形成支撑层和粘合层，其中粘合层的制备步骤是使用粘合层组合物通过混合一种碱金属二乙酸盐、一种药物和一种非水粘合基材料形成，使得药物和碱金属二乙酸盐的摩尔比（药物的摩尔数：碱金属二乙酸盐的摩尔数）在1:0.5到1:15之间。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。
• DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET
  申请人：FUJI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP2465539A1

  公开（公告）日：2012-06-20

  There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.

  人们需要一种口服快速崩解片剂，这种片剂在口腔中具有良好的质地和口感，有足够的硬度，不会担心在生产或运输过程中碎裂或沾上灰尘，在口腔中具有良好的崩解性能，即使在开封后潮湿的条件下也能保持足够的硬度。本发明公开了一种崩解颗粒组合物，其制备方法是在有水存在的情况下，将甘露醇、木糖醇、无机赋形剂、崩解剂和卡麦芽糖分散并干燥；还公开了一种口服快速崩解片剂，其包括所述崩解颗粒组合物、活性物质和崩解剂。该崩解片具有良好的质地和口感、适当的硬度和良好的崩解性能，并能在潮湿条件下保持足够的硬度。
• METHOD FOR PRODUCING ADHESIVE PATCH, AND ADHESIVE PATCH
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP2700401A1

  公开（公告）日：2014-02-26

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug : the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产包括支撑层和粘合剂层的贴片的方法，包括以下步骤：使用通过混合碱金属二乙酸酯、药物和非水粘合剂基质得到的粘合剂层组合物形成粘合剂层，使药物和碱金属二乙酸酯之间的摩尔比（药物的摩尔数：碱金属二乙酸酯的摩尔数）为 1:0.5 至 1:15。