[3,4-di(3,4,5-trimethoxyphenyl)-2-furyl]methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: [3,4-di(3,4,5-trimethoxyphenyl)-2-furyl]methanamine
• 英文别名: [3,4-Di(3,4,5-trimethoxyphenyl)-2-furyl]methan-amine；[3,4-bis(3,4,5-trimethoxyphenyl)furan-2-yl]methanamine
• 化学式: C₂₃H₂₇NO₇
• 分子量: 429.47
• InChiKey: ATVHMKSEIAMOJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [3,4-di(3,4,5-trimethoxyphenyl)-2-furyl]methanamine 、 苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以86%的产率得到N-[3,4-di(3,4,5-trimethoxyphenyl)-2-furyl]methylbenzenesulfonamide
  参考文献：
  名称：

  Design, Synthesis and Anticancer Evaluation of Novel Furan Sulphonamide Derivatives

  摘要：

  A series of novel furan sulphonamide derivatives 13a-13j was synthesized. The structures of the compounds are confirmed by H-1 and C-13 NMR, and mass spectra. All newly synthesized compounds were evaluated for their anticancer activity against three human cancer cell lines, including breast cancer cell (MCF-7), lung cancer cell (A549) and melanoma cancer cell (A-375). The compounds 13a-13c, 13e, 13g-13j demonstrated the activity higher than the positive control.

  DOI：

  10.1134/s1070363219030204
• 作为产物：
  描述：

  3,4,5-三甲氧基苯乙酸 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 盐酸羟胺 、 二异丁基氢化铝 、 三乙胺 、 potassium hydroxide 、 sodium hydroxide 、 三氯氧磷 作用下， 以 四氢呋喃 、 乙醇 、 乙腈 为溶剂， 反应 26.5h， 生成 [3,4-di(3,4,5-trimethoxyphenyl)-2-furyl]methanamine
  参考文献：
  名称：

  Design, Synthesis and Anticancer Evaluation of Novel Furan Sulphonamide Derivatives

  摘要：

  A series of novel furan sulphonamide derivatives 13a-13j was synthesized. The structures of the compounds are confirmed by H-1 and C-13 NMR, and mass spectra. All newly synthesized compounds were evaluated for their anticancer activity against three human cancer cell lines, including breast cancer cell (MCF-7), lung cancer cell (A549) and melanoma cancer cell (A-375). The compounds 13a-13c, 13e, 13g-13j demonstrated the activity higher than the positive control.

  DOI：

  10.1134/s1070363219030204

文献信息

• Design, Synthesis and Anticancer Evaluation of Novel Furan Sulphonamide Derivatives
  作者：G. Purna Chander Rao、V. Ramesh、D. Ramachandran、A. Kalyan Chakravarthy

  DOI：10.1134/s1070363219030204

  日期：2019.3

  A series of novel furan sulphonamide derivatives 13a-13j was synthesized. The structures of the compounds are confirmed by H-1 and C-13 NMR, and mass spectra. All newly synthesized compounds were evaluated for their anticancer activity against three human cancer cell lines, including breast cancer cell (MCF-7), lung cancer cell (A549) and melanoma cancer cell (A-375). The compounds 13a-13c, 13e, 13g-13j demonstrated the activity higher than the positive control.