sodium 5-aminonaphthalene-1-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: sodium 5-aminonaphthalene-1-sulfonate
• 英文别名: anhydrous sodium 1-aminonaphthalene-5-sulfonate；sodium 1-naphthylamine-5-sulfonate；1-Amino-naphthalin-5-sulfonsaeure；Sodium 1-aminonaphthalene-5-sulfonate；sodium;5-aminonaphthalene-1-sulfonate
• 化学式: C₁₀H₈NO₃S*Na
• 分子量: 245.234
• InChiKey: AUFPJRJXPQIVDT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.67
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sodium 5-aminonaphthalene-1-sulfonate 在 氯磺酸 作用下， 生成 N-[5-[(苯基氨基)磺酰基]-1-萘基]乙酰胺
  参考文献：
  名称：

  Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors

  摘要：

  HIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. In the present study, we have designed, synthesized and tested a series of caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Among these compounds, we found that HIV integrase inhibitory activities of compounds III-3 and III-4 were more potent than L-chicoric acid (IC50 = 11.8 mug/mL) and others were comparable to L-chicoric acid. Furthermore, the structure-activity relationships of these compounds were studied. The information gathered from this paper will be useful in the development and design of HIV-1 integrase inhibitors in the future. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00372-9

文献信息

• Synthesis, application and investigation of structure–thermal stability relationships of thermally stable water-soluble azo naphthalene dyes for LCD red color filters
  作者：Young Do Kim、Jung Hyun Cho、Chong Rae Park、Jae-Hong Choi、Chun Yoon、Jae Pil Kim

  DOI：10.1016/j.dyepig.2010.07.008

  日期：2011.4

  isomeric water-soluble azo naphthalene dyes were synthesized, and their thermal properties were examined by thermogravimetric analysis and differential scanning calorimetry. Dye-based color filters were also fabricated using the synthesized dyes. Transmittance (98.9%) at 650 nm and a wide color gamut (62.8%) were achieved using one of the color filters. All the prepared dyes had a degradation temperature

  合成了一系列结构异构的水溶性偶氮萘染料，并通过热重分析和差示扫描量热法研究了它们的热性能。还使用合成染料制造了基于染料的彩色滤光片。使用其中一种滤色镜，可以在650 nm处实现透射率（98.9％）和宽色域（62.8％）。所有制备的染料均具有高于280°C的降解温度，降解温度随​​染料结构而变化。据推测，染料的降解温度与结构异构体的分子内和分子间相互作用有关。从量子力学计算，它们的分子内相互作用是相似的。然而，降解温度通常与其密度成比例地增加。根据分子力学计算，
• Manufacture of aromatic amino compounds
  申请人：Osaka City

  公开号：US04001313A1

  公开（公告）日：1977-01-04

  A process for producing an aromatic amine comprises heating an aromatic sulfonate and a metal amide in liquid ammonia in a closed reactor at a temperature of at least 40.degree. C to produce a metal arylamide and reacting the resultant metal arylamide with water or lower aliphatic alcohol to produce an aromatic amine.

  一种制备芳香胺的方法，包括在封闭反应器中，在液氨中加热芳香磺酸盐和金属酰胺，温度至少为40℃，以产生金属芳基酰胺，并将所得的金属芳基酰胺与水或低级脂肪醇反应，以产生芳香胺。
• Development of Potent and Selective Inhibitors of <i>ecto</i>-5′-Nucleotidase Based on an Anthraquinone Scaffold
  作者：Younis Baqi、Sang-Yong Lee、Jamshed Iqbal、Peter Ripphausen、Anne Lehr、Anja B. Scheiff、Herbert Zimmermann、Jürgen Bajorath、Christa E. Müller

  DOI：10.1021/jm901851t

  日期：2010.3.11

  ecto-5'-Nucleotidase (eN, CD73) plays it major role in controlling extracellular adenosine levels. eN inhibitors have potential its novel drugs, for example, for the treatment of cancer. In the present study, we synthesized and investigated a series of 55 anthraquinone derivatives as potential inhibitors of eN, I I of which are novel compounds and another I I of which had previously been described but have now been synthesized by all improved method. We identified several potent inhibitors of rat eN. The most potent compounds were 1-amino-4-[4-fluoro-2-carboxyphenylamino]-9, 10-dioxo-9, 10-dihydroanthracene-2-sulfonate (45, PSB-0952, K-i = 260 nM) and 1-amino-4-[2-anthracenylamino]-9, 10-dioxo-9, 10-dihydroanthracene-2-sulfonate (52, PSB-0963, 150 nM), with 52 being the most potent eN inhibitor described to date. Selected compounds were further characterized and found to exhibit a competitive mechanism of inhibition. Investigations of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the P2Y receptor subtypes P2Y(2), P2Y(4), P2Y(6), and P2Y(12) showed that compound 45 exhibited the highest degree of selectivity (> 150-fold).
• Rieche,A.; Seeboth,H., Justus Liebigs Annalen der Chemie, 1960, vol. 638, p. 101 - 110
  作者：Rieche,A.、Seeboth,H.

  DOI：——

  日期：——
• KUTKEVICHUS S. I.; BORIK A. G.; FILICHEVA T. B.; MATVEEVA M. K.; CHUDAKOV+, LIETTSR AUKSTUJU MOKUKLU MOKSVLO DARVAI. CHEMIJA IR CHEM. TESNNOL., VYSSH+
  作者：KUTKEVICHUS S. I.、 BORIK A. G.、 FILICHEVA T. B.、 MATVEEVA M. K.、 CHUDAKOV+

  DOI：——

  日期：——