(3E)-2-(4-methoxymethoxymethylphenyl)-1,6-bis-(4-methoxyphenyl)pent-3-ene-1,6-diol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (3E)-2-(4-methoxymethoxymethylphenyl)-1,6-bis-(4-methoxyphenyl)pent-3-ene-1,6-diol
• 英文别名: (E)-2-[4-(methoxymethoxymethyl)phenyl]-1,6-bis(4-methoxyphenyl)hex-3-ene-1,6-diol
• 化学式: C₂₉H₃₄O₆
• 分子量: 478.585
• InChiKey: AVOLCCQXIMTEGI-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 1-[(E)-buta-1,3-dienyl]-4-(methoxymethoxy-methyl)benzene 在 diisobutylaluminium acetylacetonate 、 镍 、 三苯基膦 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 13.0h， 以78%的产率得到(4E)-5-(4-methoxymethoxymethylphenyl)-1-(4-methoxyphenyl)pent-4-en-1-ol
  参考文献：
  名称：

  Nickel-Catalyzed Intermolecular Coupling of 1,3-Dienes and Aldehydes via Transmetalation of Nickelacycles with Diisobutylaluminum Acetylacetonate

  摘要：

  Intermolecular coupling reactions of 1,3-dienes and aldehydes via transmetalation of nickelacycle intermediate with (BU2Al)-B-i-acac were investigated. In the reactions, a linear adduct or a branched adduct was produced, depending upon the nature of 1,3-dienes and aldehydes, via two nickelacycles that were relatively stable among the four possible nickelacycles because of the equilibrium with pi-allynickel forms.

  DOI：

  10.1021/jo0106086

文献信息

• Nickel-Catalyzed Intermolecular Coupling of 1,3-Dienes and Aldehydes via Transmetalation of Nickelacycles with Diisobutylaluminum Acetylacetonate
  作者：Yoshihiro Sato、Rieko Sawaki、Nozomi Saito、Miwako Mori

  DOI：10.1021/jo0106086

  日期：2002.2.1

  Intermolecular coupling reactions of 1,3-dienes and aldehydes via transmetalation of nickelacycle intermediate with (BU2Al)-B-i-acac were investigated. In the reactions, a linear adduct or a branched adduct was produced, depending upon the nature of 1,3-dienes and aldehydes, via two nickelacycles that were relatively stable among the four possible nickelacycles because of the equilibrium with pi-allynickel forms.