三甲基-d₉-胺氯化氘 | 107766-37-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 三甲基-d₉-胺氯化氘
• 英文名称: Trimethyl-d9-amine deuteriochloride, 98 atom % D
• 英文别名: (2H)chlorane;1,1,1-trideuterio-N,N-bis(trideuteriomethyl)methanamine
• CAS: 107766-37-0
• 化学式: C₃H₉N*ClH
• 分子量: 105.493
• InChiKey: SZYJELPVAFJOGJ-HMROAWRFSA-N

物化性质

• 熔点：
  283-284 °C (dec.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三甲基-d₉-胺氯化氘 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 三甲基-d9-胺
  参考文献：
  名称：

  Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior

  摘要：

  Three Raman probes of sphingomyelin (SM) were synthesized and evaluated for their applicability to imaging experiments. One probe containing a hydroxymethyl-1,3-butadiyne moiety in the polar head group showed strong scattering. The solid-state H-2 NMR spectra of this probe in oriented bilayer membrane revealed excellent compatibility with natural SM in phase behavior since the probe undergoes phase separation to form raft-like liquid ordered (L-o) domains in the raft-mimicking mixed bilayers. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.05.014

文献信息

• A flow injection electrospray ionization tandem mass spectrometric method for the simultaneous measurement of trimethylamine and trimethylamine<i>N</i>-oxide in urine
  作者：David W. Johnson

  DOI：10.1002/jms.1339

  日期：2008.4

  Key metabolites for the diagnosis of the genetic disorder trimethylaminuria are trimethylamine (TMA) and trimethylamine N-oxide (TMAO). A rapid, automatable flow injection ESI-MS/MS method for their measurement in urine has been developed. The TMA was derivatized with ethyl bromoacetate to form ethyl betaine bromide. The 2 min ESI-MS/MS analysis employed four multiple reaction monitoring (MRM) ion pairs for derivatized TMA (146.1, 118.1), derivatized 2H9-TMA (155.1, 127.1), TMAO (76.1, 58.1) and 2H9-TMAO (85.1, 66.1). In control urine samples (n = 27) referred for suspected metabolic problems TMA was 0.11–1.19 mmol/mol creatinine, TMAO was 13.5–181 mmol/mol creatinine and the TMA/TMAO ratio was 0.0025–0.055. In five patients with diagnosed trimethylaminuria, TMA was 5.3–230 mmol/mol creatinine, TMAO was 0.36–607 mmol/mol creatinine and the TMA/TMAO ratio was 0.20–134. Copyright © 2007 John Wiley & Sons, Ltd.

  诊断遗传性疾病三甲胺尿症的关键代谢物是三甲胺（TMA）和三甲胺 N-氧化物（TMAO）。我们开发了一种快速、自动化的流动注射 ESI-MS/MS 方法，用于检测尿液中的这两种代谢物。用溴乙酸乙酯对 TMA 进行衍生，生成溴化甜菜碱乙酯。2 分钟的 ESI-MS/MS 分析采用了四个多反应监测 (MRM) 离子对：衍生化 TMA（146.1，118.1）、衍生化 2H9-TMA（155.1，127.1）、TMAO（76.1，58.1）和 2H9-TMAO（85.1，66.1）。在因疑似代谢问题而转诊的对照尿样（n = 27）中，TMA 为 0.11-1.19 mmol/mol肌酐，TMAO 为 13.5-181 mmol/mol肌酐，TMA/TMAO 比值为 0.0025-0.055。在五名确诊为三甲胺尿症的患者中，TMA为5.3-230毫摩尔/摩尔肌酐，TMAO为0.36-607毫摩尔/摩尔肌酐，TMA/TMAO比值为0.20-134。Copyright © 2007 John Wiley & Sons, Ltd. All Rights Reserved.
• Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior
  作者：Jin Cui、Shigeru Matsuoka、Masanao Kinoshita、Nobuaki Matsumori、Fuminori Sato、Michio Murata、Jun Ando、Hiroyuki Yamakoshi、Kosuke Dodo、Mikiko Sodeoka

  DOI：10.1016/j.bmc.2015.05.014

  日期：2015.7

  Three Raman probes of sphingomyelin (SM) were synthesized and evaluated for their applicability to imaging experiments. One probe containing a hydroxymethyl-1,3-butadiyne moiety in the polar head group showed strong scattering. The solid-state H-2 NMR spectra of this probe in oriented bilayer membrane revealed excellent compatibility with natural SM in phase behavior since the probe undergoes phase separation to form raft-like liquid ordered (L-o) domains in the raft-mimicking mixed bilayers. (C) 2015 Elsevier Ltd. All rights reserved.