三甲基[2-(硬脂酰氧基)乙基]氯化铵 | 25234-57-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 三甲基[2-(硬脂酰氧基)乙基]氯化铵
• 英文名称: O-stearoylcholine chloride
• 英文别名: trimethyl-(2-stearoyloxy-ethyl)-ammonium; chloride；Trimethyl-(2-stearoyloxy-aethyl)-ammonium; Chlorid；stearoylcholinium chloride；octadecanoyloxyethyl-N,N,N-trimethylammonium chloride；Trimethyl(2-(stearoyloxy)ethyl)ammonium chloride；trimethyl(2-octadecanoyloxyethyl)azanium;chloride
• CAS: 25234-57-5
• 化学式: C₂₃H₄₈NO₂*Cl
• 分子量: 406.093
• InChiKey: HHADJUZGKVNYLU-UHFFFAOYSA-M

物化性质

• 熔点：
  171 - 174 °C
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2923900090

反应信息

• 作为产物：
  描述：

  O-stearoylcholine Iodide 在 sodium chloride 作用下， 生成 三甲基[2-(硬脂酰氧基)乙基]氯化铵
  参考文献：
  名称：

  Hofmeister系列阴离子对生物活性邻乙酰胆碱热变相行为的影响

  摘要：

  O-酰基胆碱（OAC）是真正的阳离子脂质，归因于头基团中的季铵盐官能团，具有有趣的生物学活性和药用特性。在本研究中，已合成了具有相同链长（n = 12–20）的OAC同源序列，并已表征了它们的热致和离液相变。各种阴离子（Cl –，Br –，I –，NO 3 –，SO 4 2–，ClO 3 –，ClO 4 –）对O的相行为的作用-硬脂酰胆碱通过量热法，分光镜法和比浊法进行了研究。所获得的结果表明，在水分散体中，O-硬脂酰胆碱经历了从凝胶相到胶束结构的协同相变，并且当霍夫迈斯特系列中的抗衡离子发生变化时，转变温度升高。单晶X射线衍射研究表明，O-硬脂酰胆碱碘化物形成叉指状双层结构，而聚亚甲基链采用全反式构象。使用匹配的水亲和力，渗入双层的水和静电排斥的概念解释了Hofmeister效应和相行为。。还观察到每个分子一个抗衡离子足以强烈调节脂质/表面活性剂的相性质。

  DOI：

  10.1021/jp403964k

文献信息

• Softener composition
  申请人：Ushio Noriaki

  公开号：US20050090423A1

  公开（公告）日：2005-04-28

  A softener composition that can impart a high softening effect to clothes irrespective of the state of rinsing water, which contains (a) a compound of formula (1) below, (b) a compound of formula (3) below, and (c) a specific anionic surfactant, wherein the mole ratios between the components (a), (b) and (c) satisfy the following relationship: [(a)+(b)]/(c)=9/1 to 4/6; and wherein R 1 represents a C 13-36 alkyl group or the like, R 10 and R 12 respectively represent a C 8-36 alkyl group or the like, R 2 , R 11 and R 13 respectively represent a C 1-6 alkylene group, R 3 , R 4 , and R 14 respectively represent a C 1-3 alkyl group or the like, A, D and E respectively represent —COO—, —CONH— or the like, and “a”, “c” and “d” respectively denote 0 or 1.

  一种软化剂组合物，可以在漂洗水的状态不同的情况下赋予衣物高度的柔软效果，该组合物包含以下的化合物：(a) 下式的化合物，(b) 下式的化合物，以及(c) 特定的阴离子表面活性剂，其中组分(a)、(b)和(c)之间的摩尔比满足以下关系：[(a)+(b)]/(c)=9/1至4/6；其中R1代表C13-36烷基基团或类似物，R10和R12分别代表C8-36烷基基团或类似物，R2、R11和R13分别代表C1-6烷基烯基基团，R3、R4和R14分别代表C1-3烷基基团或类似物，A、D和E分别代表—COO—、—CONH—或类似物，“a”、“c”和“d”分别表示0或1。
• Sustained release pharmaceutical compositions
  申请人：Zhang Yongfeng Jack

  公开号：US20070154546A1

  公开（公告）日：2007-07-05

  The present invention relates to a pharmaceutical composition comprising a salt of quaternary ammonium of an acid drug in the form of a suspension or an emulsion, suitable for parenteral administration and providing a sustained release of the drug. In one preferred embodiment, the present invention is directed to a long term sustained release composition for parenteral administration, comprising a salt of heparin or low molecular weight heparin in an emulsion with a salt of acylcholine, for the prevention and treatment of venous thrombosis and pulmonary embolism.

  本发明涉及一种制药组合物，包括酸性药物的季铵盐，其以悬浮液或乳状液的形式适用于肌内给药，并提供药物的持续释放。在一个优选实施例中，本发明涉及一种用于肌内给药的长期持续释放组合物，包括肝素盐或低分子量肝素与乙酰胆碱盐的乳状液，用于预防和治疗静脉血栓和肺栓塞。
• Use of a (1>3)-Beta-D-Glucan as an Emulsion Stabiliser
  申请人：Lommerts Bert Jan

  公开号：US20110168055A1

  公开（公告）日：2011-07-14

  The present invention relates to the use of a (1→3)-β-D-glucan as an emulsion stabiliser. The present invention further relates to emulsions comprising a (1→3)-β-D-glucan in an amount of 0.01 to 10 wt. %, based on the total weight of the emulsion. The present invention also relates to bitumen binder compositions comprising a (1→3)-β-D-glucan in an amount of 0.005 to less than 0.1 wt. %, based on the total weight of the bitumen binder composition. The present invention further relates to emulsions comprising a novel biodegradable emulsifying agent, in particular in combination with a (1→3)-β-D-glucan.

  本发明涉及使用(1→3)-β-D-葡聚糖作为乳化稳定剂。本发明还涉及含有(1→3)-β-D-葡聚糖的乳液，其重量百分比为0.01至10％，基于乳液的总重量。本发明还涉及含有(1→3)-β-D-葡聚糖的沥青粘合剂组合物，其重量百分比为0.005至少于0.1％，基于沥青粘合剂组合物的总重量。本发明还涉及含有新型可生物降解乳化剂的乳液，特别是与(1→3)-β-D-葡聚糖结合的乳化剂。
• Low-phosphate detergent composition for fabric washing
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0000595A1

  公开（公告）日：1979-02-07

  Laundry detergent compositions containing specific mixtures of selected nonionic surfactants, selected cationic surfactants and fatty amide surfactants are disclosed. These compositions are unusually effective in removing soils, especially particulate soiis, from fabrics, and preventing their redeposition onto the fabrics during the laundering process.

  本发明公开了含有精选非离子表面活性剂、精选阳离子表面活性剂和脂肪酰胺表面活性剂特定混合物的洗衣粉组合物。这些组合物能异常有效地去除织物上的污垢，尤其是微粒污垢，并防止它们在洗涤过程中重新沉积到织物上。
• ANTI-STATIC BICOMPONENT FORMULATION FOR UNSATURATED POLYESTER RESINS AND EPOXY VINYL ESTER RESINS
  申请人：Avanzare Innovacion Tecnologica S.L.

  公开号：EP3345965A1

  公开（公告）日：2018-07-11

  The invention relates to a novel formulation based on two components, which, when added to items produced with epoxy vinyl ester or unsaturated polyester resin, provides same with electric charge dissipation and/or antistatic characteristics, maintaining the mechanical characteristics thereof and the possibility of dyeing the material in all of the possible colour ranges. The formulation has a first component which is an active substance which is an ionic salt that allows ion mobility, the cation being a compound based on the (R4)N,N,N-trialkyl-alkyl-ol-ammonium species, as it is or derivatised on the OH group, and a system that supports said active substance. This additive or formulation added to epoxy vinyl ester or unsaturated polyester resin can be used in the production of agglomerated stone, gel coat, sheet moulding composite or bulk moulding composite.

  本发明涉及一种基于两种成分的新型配方，当将其添加到用环氧乙烯基酯或不饱和聚酯树脂生产的物品中时，可为其提供电荷消散和/或抗静电特性，同时保持其机械特性，并可在所有可能的颜色范围内对材料进行染色。配方中的第一种成分是一种活性物质，它是一种允许离子移动的离子盐，阳离子是一种基于(R4)N,N,N-三烷基-烷基-醇-铵种类的化合物，如其本身或在羟基上衍生的化合物，以及一种支持所述活性物质的体系。这种添加剂或配方添加到环氧乙烯基酯或不饱和聚酯树脂中，可用于生产团聚石、胶衣、片状模塑复合材料或块状模塑复合材料。