Fmoc-(6-methyl)-L,D-Tryptopan

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-(6-methyl)-L,D-Tryptopan
• 英文别名: Fmoc-6-methyl-DL-tryptophan；2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(6-methyl-1H-indol-3-yl)propanoic acid
• 化学式: C₂₇H₂₄N₂O₄
• 分子量: 440.499
• InChiKey: AZYYHRQGDYITPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  91.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Fmoc-L-异亮氨酸 、 3-[3-[(2-Methylpropan-2-yl)oxycarbonyl]-1,3-oxazinan-2-yl]propanoic acid 、 Fmoc-(6-methyl)-L,D-Tryptopan 生成 2-{2-[1-((1S,2S)-1-Carboxy-2-methyl-butylcarbamoyl)-2-(6-methyl-1H-indol-3-yl)-ethylcarbamoyl]-ethyl}-[1,3]oxazinane-3-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Nielsen, Thomas E.; Meldal, Morten, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3765 - 3773

  摘要：

  DOI：

文献信息

• Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53
  作者：Carlos García-Echeverría、Patrick Chène、Marcel J. J. Blommers、Pascal Furet

  DOI：10.1021/jm990966p

  日期：2000.8.1
• Identification of Compounds Modifying a Cellular Response
  申请人：Hagel Grith

  公开号：US20110319274A1

  公开（公告）日：2011-12-29

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. Test compounds modulating a cellular response, for example via a cell surface molecule may be identified by selecting solid supports comprising cells, wherein the cellular response of interest has been modulated. The cellular response may for example be changes in signal transduction pathways modulated by a cell surface molecule.
• METHOD OF IMPROVING PLANT PERFORMANCE
  申请人：The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization

  公开号：US20200383327A1

  公开（公告）日：2020-12-10

  Provided composition and methods for controlling, treating or preventing a pathogenic infection in a plant with a phenylalanine solution. The plant may be at a post-harvest and/or at a pre-harvest stage.
• Nielsen, Thomas E.; Meldal, Morten, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3765 - 3773
  作者：Nielsen, Thomas E.、Meldal, Morten

  DOI：——

  日期：——