5'-Ethyl-[2,2']bithiophenyl-5-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: 5'-Ethyl-[2,2']bithiophenyl-5-carbaldehyde
• 英文别名: 5-(5-Ethylthiophen-2-yl)thiophene-2-carbaldehyde
• 化学式: C₁₁H₁₀OS₂
• mdl: MFCD01812669
• 分子量: 222.332
• InChiKey: BBWZVSFQWLWURW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5'-Ethyl-[2,2']bithiophenyl-5-carbaldehyde 生成 (NE)-N-[[5-(5-ethylthiophen-2-yl)thiophen-2-yl]methylidene]hydroxylamine
  参考文献：
  名称：

  CHURKIN, YU. D.;RUDZIT, EH. A.;PANFILOVA, L. V.;KULIKOVA, D. A.

  摘要：

  DOI：
• 作为产物：
  描述：

  5-Aethyl-2,2'-bithiophen 生成 5'-Ethyl-[2,2']bithiophenyl-5-carbaldehyde
  参考文献：
  名称：

  CHURKIN, YU. D.;RUDZIT, EH. A.;PANFILOVA, L. V.;KULIKOVA, D. A.

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX
  申请人：Deng Huayun

  公开号：US20120022116A1

  公开（公告）日：2012-01-26

  Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject. The compounds having a formula (I), (II) or (III):

  揭示了与GPR35及/或GPR35-hERG信号复合物在病理生理上相关的疾病的预防和/或治疗的组合物和方法。例如，揭示了用于预防和/或治疗与GPR35在受试者中病理生理相关的疾病的化合物。这些化合物具有以下公式(I)、(II)或(III)：
• Biologically active thiophene derivatives. IV. Synthesis and antiviral activity of unsaturated ketones of the thiophene series
  作者：Yu. D. Churkin、L. V. Panfilova、E. I. Boreko、M. M. Timofeeva、V. I. Votyakov

  DOI：10.1007/bf00762027

  日期：1982.2

  ar R = C~Hs; R' =5'-methyl-2,2'-dithienyl-5-yl; b: R = 2-furyl; R ~ = 2,2~-dithieny!-5-yl; c: R = 2-furyl; R' = 5'-methyl-2~2'-dithienyl-5-y!; d: R = 2-thienyl; R ~ = 5'-methyl-2,2'dithienyl-5-yi; e: R = 2-thienyl; R' = 2,2'-dithienyl-5-yl; f: R = 2,2'-dithienyi; R' = 2-thienyi; g: R = 2,2'-dithienyi-5-yl; R' = 5'-methvl-2.2'-dithienvl-5-vl: h: R = 5 ~methyl-2,2'-dithienyl-5-yl;* i: R = 5'~methyl-2

  ar R = C~Hs; R' = 5'-甲基-2,2'-二噻吩基-5-基；b: R = 2-呋喃基；R~=2,2~-二噻吩！-5-基；c: R = 2-呋喃基；R' = 5'-methyl-2~2'-dithienyl-5-y!; d：R = 2-噻吩基；R~=5'-甲基-2，2'二噻吩基-5-yi；e: R = 2-噻吩基；R' = 2,2'-二噻吩基-5-基；f: R = 2,2'-二噻吩；R' = 2-thienyi; g：R = 2,2'-二噻吩基-5-基；R' = 5'-methvl-2.2'-dithienvl-5-vl: h: R = 5 ~methyl-2,2'-dithienyl-5-yl;* i: R = 5'~methyl-2,2' -dithieny!-5-yl; R' = 2-呋喃基；j：R = 5'methyl-2,2'-dithienyl-5-y!；R'=2-噻吩基；k：R
• CHURKIN, YU. D.;PANFILOVA, L. V.;BOREKO, E. I.;TIMOFEEVA, M. M.;VOTYAKOV,+, XIM.-FARMATS. ZH., 1982, 16, N 2, 167-169
  作者：CHURKIN, YU. D.、PANFILOVA, L. V.、BOREKO, E. I.、TIMOFEEVA, M. M.、VOTYAKOV,+

  DOI：——

  日期：——
• CHURKIN, YU. D.;RUDZIT, EH. A.;PANFILOVA, L. V.;KULIKOVA, D. A.
  作者：CHURKIN, YU. D.、RUDZIT, EH. A.、PANFILOVA, L. V.、KULIKOVA, D. A.

  DOI：——

  日期：——