(1S,3R,8R,11S)-11-bromo-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6.4.0.0^1,3]dodec-9-ene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: (1S,3R,8R,11S)-11-bromo-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6.4.0.0^1,3]dodec-9-ene
• 英文别名: (1S,3R,8R,11S)-11-bromo-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6.4.0.01,3]dodec-9-ene
• 化学式: C₁₆H₂₃BrCl₂
• 分子量: 366.169
• InChiKey: BDQSCVZZIWJYAN-MXYBEHONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (1S,3R,8R)-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6.4.0.0^1,3]dodec-9-ene 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以10%的产率得到(1S,3R,8R)-10-Bromomethyl-2,2-dichloro-3,7,7-trimethyltricyclo[6.4.0.0^1,3^]dodec-9-ene
  参考文献：
  名称：

  Optimization of Allylic Oxidation of (1S,3R,8R)‐2,2‐Dichloro‐3,7,7,10‐tetramethyltricyclo[6,4,0,0^1,3]dodec‐9‐ene

  摘要：

  The allylic oxidation of (IS,3R,8R)-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6,4,0,0(1,3)]dodec-9-ene into the corresponding enone with N-bromo-succinimide (NBS), CrO3 and t-BuOOH has been studied. A good yield and high selectivity were obtained in the presence of t-BuOOH and a copper catalyst.

  DOI：

  10.1081/scc-120037912

文献信息

• Optimization of Allylic Oxidation of (1S,3R,8R)‐2,2‐Dichloro‐3,7,7,10‐tetramethyltricyclo[6,4,0,0^1,3]dodec‐9‐ene
  作者：M. Dakir、A. Auhmani、My. Y. Ait Itto、N. Mazoir、M. Akssira、M. Pierrot、A. Benharref

  DOI：10.1081/scc-120037912

  日期：2004.12.31

  The allylic oxidation of (IS,3R,8R)-2,2-dichloro-3,7,7,10-tetramethyltricyclo[6,4,0,0(1,3)]dodec-9-ene into the corresponding enone with N-bromo-succinimide (NBS), CrO3 and t-BuOOH has been studied. A good yield and high selectivity were obtained in the presence of t-BuOOH and a copper catalyst.