丙基烯丙基三硫醚 | 33922-73-5

• 物质功能分类: 香精与香料 - 合成香料 - 硫醚类香料
• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机三硫化物
• 中文名称: 丙基烯丙基三硫醚
• 中文别名: 2-烯丙基丙基三硫化物；2-丙烯基三硫丙酯
• 英文名称: 1-allyl-3-propyltrisulfane
• 英文别名: allyl propyl trisulfide；1-(prop-2-enyltrisulfanyl)propane
• CAS: 33922-73-5
• 化学式: C₆H₁₂S₃
• mdl: MFCD00085182
• 分子量: 180.359
• InChiKey: IXJMGVJLUBBAQW-UHFFFAOYSA-N

物化性质

• LogP：
  3.666 (est)
• 保留指数：
  1290;1297;1290

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  75.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Acetyl-aethyldisulfid 、 allyl thiotosylate 在 sodium methylate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.18h， 以95%的产率得到丙基烯丙基三硫醚
  参考文献：
  名称：

  Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate

  摘要：

  New methodology is presented for the formation of unsymmetrical organotrisulfides in a high yield and purity, relatively free of polysulfide byproducts. The highlight of the method is the low-temperature (-78 degrees C) deprotection of a disulfanyl acetate with sodium methoxide in THF to form a disulfanyl anion, which reacts rapidly in situ with an organothiosulfonate (S-aryl or S-alkyl) within 30 seconds followed by quenching. The discovery of these new reaction conditions together with the relative greenness of the chemistry overall makes for an efficient protocol, from which a range of organotrisulfides covering aliphatic, aromatic, as well as cysteine and sugar groups can be accessed in a high yield and purity.

  DOI：

  10.1021/acs.joc.8b03262

文献信息

• COMPOSITIONS COMPRISING COENZYME Q-10 AND GARLIC OIL FOR AN INCREASED COENZYME Q-10 BIOAVAILABILITY
  申请人：Cpc (Tianjin) Fine Chemicals Co., Ltd.

  公开号：EP2227229A2

  公开（公告）日：2010-09-15
• USE OF GARLIC OIL TO INCREASE BIOAVAILABILITY OF COENZYME Q-10
  申请人：Shi Jingang

  公开号：US20090143484A1

  公开（公告）日：2009-06-04

  The invention describes compositions that include a sulfide containing molecule, such a garlic oil, and a coenzyme Q molecule. The sulfide containing molecule solvates the coenzyme Q molecule, thus enhancing the bioavailability of the coenzyme Q molecule in a subject in need thereof, relative to administration of coenzyme Q devoid of the presence of a sulfide containing molecule.
• [EN] USE OF GARLIC OIL TO INCREASE BIOAVAILABILITY OF COENZYME Q-10<br/>[FR] UTILISATION D'ESSENCE D'AIL POUR AUGMENTER LA BIODISPONIBILITÉ DE LA COENZYME Q-10
  申请人：CPC TIANJIN FINE CHEMICALS CO

  公开号：WO2009073661A2

  公开（公告）日：2009-06-11

  The invention describes compositions that include a sulfide containing molecule, such a garlic oil, and a coenzyme Q molecule. The sulfide containing molecule solvates the coenzyme Q molecule, thus enhancing the bioavailability of the coenzyme Q molecule in a subject in need thereof, relative to administration of coenzyme Q devoid of the presence of a sulfide containing molecule.
• [EN] COMPOSITIONS COMPRISING COENZYME Q-10 AND GARLIC OIL FOR AN INCREASED COENZYME Q-10 BIOAVAILABILITY<br/>[FR] COMPOSITIONS COMPRENANT LA COENZYME Q-10 ET DE L'ESSENCE D'AIL POUR UNE BIODISPONIBILITÉ ACCRUE DE LA COENZYME Q-10
  申请人：CPC TIANJIN FINE CHEMICALS CO

  公开号：WO2009073659A1

  公开（公告）日：2009-06-11

  The invention describes compositions that include a sulfide containing molecule, such a garlic oil, and a coenzyme Q molecule. The sulfide containing molecule solvates the coenzyme Q molecule, thus enhancing the bioavailability of the coenzyme Q molecule in a subject in need thereof, relative to administration of coenzyme Q devoid of the presence of a sulfide containing molecule.