2-amino-4-((8S,9S,10R,13S,14S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13, 14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)thiophene-3-carbonitrile

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-amino-4-((8S,9S,10R,13S,14S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13, 14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)thiophene-3-carbonitrile
• 英文别名: 2-amino-4-[(8S,9S,10R,13S,14S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]thiophene-3-carbonitrile
• 化学式: C₂₄H₃₀N₂OS
• 分子量: 394.581
• InChiKey: BHAWMUSPMODDNP-XOYUQFJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  95.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  黄体酮 在 ammonium acetate 、 sulfur 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 2-amino-4-((8S,9S,10R,13S,14S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13, 14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)thiophene-3-carbonitrile
  参考文献：
  名称：

  Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines

  摘要：

  Progesterone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1, through its reaction with active methylene derivatives, gave the condensate derivatives 3a, b. The latter compounds underwent heterocyclization reactions through the reaction with either hydrazine hydrate or phenyl hydrazine to give the pyrazole derivatives 6a-d, respectively. The reaction of 1 with bromine gave the alpha-bromo derivative 7, which in turn reacted with potassium cyanide to yield the cyanoacetyl derivative 8. Compound 8 has been subjected to a series of reactions that produced benzylidene, aryl hydrazine, pyrazole, and pyran derivatives. The newly synthesized products were tested for their efficiency as pneumococcal vaccines and the results were promising.

  DOI：

  10.1007/s00044-013-0894-8

文献信息

• Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines
  作者：Rafat M. Mohareb、Fatma O. Al Farouk、Sherif M. Sherif、Konstantin Karaghiosoff

  DOI：10.1007/s00044-013-0894-8

  日期：2014.6

  Progesterone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1, through its reaction with active methylene derivatives, gave the condensate derivatives 3a, b. The latter compounds underwent heterocyclization reactions through the reaction with either hydrazine hydrate or phenyl hydrazine to give the pyrazole derivatives 6a-d, respectively. The reaction of 1 with bromine gave the alpha-bromo derivative 7, which in turn reacted with potassium cyanide to yield the cyanoacetyl derivative 8. Compound 8 has been subjected to a series of reactions that produced benzylidene, aryl hydrazine, pyrazole, and pyran derivatives. The newly synthesized products were tested for their efficiency as pneumococcal vaccines and the results were promising.