bis-o-aminothio-phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: bis-o-aminothio-phenol
• 英文别名: ortho-aminothiophenol；2-amino-thiophenol；amino-thiophenol；bis-o-aminothiophenol；2-aminothio phenol；2-aminothio-phenol；Amino(thio)phenol；2-aminosulfanylphenol
• 化学式: C₆H₇NOS
• 分子量: 141.194
• InChiKey: BHIDHAWQLYOKFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis-o-aminothio-phenol 、 3-氨基丙腈 以 乙醇 为溶剂， 反应 6.0h， 生成 2-苯并噻唑乙胺(9ci)
  参考文献：
  名称：

  [EN] SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS
  [FR] 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES SUBSTITUEES EN TANT QU'INHIBITEURS DE LA GSK-3

  摘要：

  这项发明涉及到式(I)化合物及其前药，以及该化合物和前药的药用可接受盐，其中Ra、Rb、R1和R2如本文所定义；药物组合物；以及它们的用途。

  公开号：

  WO2005035532A1

文献信息

• Benzothiazepines
  申请人：Roussel Uclaf

  公开号：US05063225A1

  公开（公告）日：1991-11-05

  A compound selected from the group consisting of all possible isomeric forms, racemic or optically active of a compound of the formula ##STR1## wherein the substituents are defined in the specification, and their non-toxic, pharmaceutically acceptable acid addition salts having antiarhythmic activity.

  从所有可能的同分异构体、消旋体或光学活性化合物中选择的一种化合物，其化学式为##STR1##，其中取代基在规范中定义，并且其无毒、药用可接受的酸盐具有抗心律失常活性。
• [EN] NOVEL COMPOUNDS AND THEIR USE<br/>[FR] NOUVEAUX COMPOSÉS ET LEUR UTILISATION
  申请人：DEBIOPHARM INT SA

  公开号：WO2021123372A1

  公开（公告）日：2021-06-24

  The present invention provides compounds of the general formula (I) or a pharmaceutically acceptable prodrugs, salts and/or solvates thereof, wherein LHS is selected from the group consisting of LHSa and LHSb And wherein, the asterisk (*) marks the point of attachment; These compounds exhibit antibacterial activity against Gram-negative and Gram-positive bacteria, especially S. aureus, E. coli, K. pneumoniae and A. baumannii. Pharmaceutical compositions containing these compounds, therapeutic uses thereof and methods for manufacturing the same are also provided.

  本发明提供了一般式（I）的化合物或其药用可接受的前药、盐和/或溶剂化合物，其中LHS选自LHSa和LHSb组成的组，星号（*）标记附着点；这些化合物对革兰氏阴性和革兰氏阳性细菌，特别是金黄色葡萄球菌、大肠杆菌、肺炎克雷伯菌和鲍曼不动杆菌表现出抗菌活性。还提供了含有这些化合物的药物组合物、其治疗用途和制备方法。
• 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake
  申请人：ELI LILLY AND COMPANY

  公开号：EP0812826A1

  公开（公告）日：1997-12-17

  The pharmaceutical use of novel compounds of formula I: where Z is a structure of formula A-B is -C=CH- or -C(R5)-CH2-; X is S or NR4; R1 is H, halo, formyl, C1-C4 alkyl, C1-C4 alkoxy, thienylmethyloxy, 4,5-dihydrothiazol-2-yl, cyano, nitro, carboxamido, trifluoromethyl or hydroxy; R2 is H or halo; R3 is H, C1-C4 alkyl, (C1-C4 alkylene)-aryl, or -CH2-Y-NR7R8; R4 is H, C1-C4 alkyl, C1-C5 acyl, or phenylsulfonyl; R5 is H or OH; R6 is H or methyl; Y is -CH2- or -C(O)-; R7 is pyridinyl; and R8 is H or -C(O)-(C3-C6 cycloalkyl); and pharmaceutically acceptable salts thereof.

  化合物的药用途：其中Z是formulaA-B结构，-C=CH-或-C(R5)-CH2-；X是S或NR4；R1是H、卤素、甲酰基、C1-C4烷基、C1-C4烷氧基、噻吩甲氧基、4,5-二氢噻唑-2-基、氰基、硝基、羧酰胺基、三氟甲基或羟基；R2是H或卤素；R3是H、C1-C4烷基、(C1-C4烷基)-芳基，或-CH2-Y-NR7R8；R4是H、C1-C4烷基、C1-C5酰基，或苯基磺酰基；R5是H或OH；R6是H或甲基；Y是-CH2-或-C(O)-；R7是吡啶基；R8是H或-C(O)-(C3-C6环烷基)；以及其药用上可接受的盐。
• 2-Aryl-5-trifluoromethylpyridines
  申请人：——

  公开号：US20040043903A1

  公开（公告）日：2004-03-04

  The present invention relates to 2-aryl-5-trifluoromethylpyridines of the formula I 1 in which the variables m, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X have the meanings given in claim 1, and their agriculturally tolerated salts. Moreover, the invention relates to the use of compounds I and their salts as herbicides and/or for the desiccation and/or defoliation of plants, to herbicidal compositions and compositions for the desiccation and/or defoliation of plants comprising the compounds I and/or their salts as active substances.

  本发明涉及具有以下通式I中给定的变量m、R1、R2、R3、R4、R5、R6和X含义的2-芳基-5-三氟甲基吡啶，以及它们在农业中可容忍的盐。此外，本发明涉及化合物I及其盐作为除草剂和/或用于植物干燥和/或落叶的用途，以及包含化合物I和/或其盐作为活性物质的除草剂组合物和用于植物干燥和/或落叶的组合物。
• ANDROGRAPHOLIDE ANALOGS AND THEIR USE FOR MEDICATION
  申请人：LIAONING LIFENG SCIENTIFIC & TECHNOLOGY DEVELOPMENT COMPANY LTD.

  公开号：US20150150893A1

  公开（公告）日：2015-06-04

  This invention relates to novel andrographolide analogs of formula I that are useful for the treatment, prevention and/or amelioration of human diseases of viruses and cancers. This invention also relates with their pharmaceutical compositions, preparative methods and applications.

  本发明涉及式I的新型andrographolide类似物，其可用于治疗、预防和/或改善病毒和癌症等人类疾病。本发明还涉及它们的制药组合物、制备方法和应用。