丙酮醛二(N4-甲基缩氨基硫脲) | 673-68-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丙酮醛二(N4-甲基缩氨基硫脲)
• 英文名称: Pyruvaldehyde bis(N4,N4-dimethylthiosemicarbazone)
• 英文别名: 1-methyl-3-[(E)-[(1E)-1-(methylcarbamothioylhydrazinylidene)propan-2-ylidene]amino]thiourea
• CAS: 673-68-7
• 化学式: C₇H₁₄N₆S₂
• 分子量: 246.4
• InChiKey: VEXRMMJOMMTPKJ-ZVSIBQGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  137
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090

文献信息

• Miniaturized 62zn/62cu generator for high concentration clinical delivery of 62cu kit formulation for the facile preparation of radiolabeled cu-bis(thiosemicarbazone)compounds
  申请人：Lacy L. Jeffrey

  公开号：US20060275208A1

  公开（公告）日：2006-12-07

  A new system accomplishes easy, interchangeable production of multiple PET radiopharmaceuticals through the use of a simplified eluant-only generator and a kit based synthesis technique employing lyophilized or freeze dried ligand. Thus, by simply switching the lyophilized ligand vial kit, any number of 62 Cu-labeled radiopharmaceuticals ( 62 Cu-ligand) can be interchangeably synthesized with only one 62 Zn/ 62 Cu generator.

  一种新系统通过使用简化的仅洗脱剂发生器和基于冻干或冷冻干燥配体的套件合成技术，实现了多种PET放射性药物的易于交换的生产。因此，通过简单地切换冻干配体瓶套件，可以使用仅一个62Zn/62Cu发生器交替合成任意数量的62Cu标记的放射性药物（62Cu配体）。
• Radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative
  申请人：NIHON MEDI-PHYSICS Co., Ltd.

  公开号：EP0726077A2

  公开（公告）日：1996-08-14

  The present invention relates to a diagnostic agent for hypoxia or mitochondrial dysfunction comprising: (a) a radioactive copper complex of a dithiosemicarbazone derivative or a radioactive copper complex of a diamine diol schiff base derivative as defined in claim 1; and (b) a pharmaceutically acceptable diluent or carrier. The diagnostic agent according to the present invention has a good transferability to the target tissue, reduction reaction affinity at a hypoxic site, high stability in a non-target site and rapid disappearance ability therefrom.

  本发明涉及一种缺氧或线粒体功能障碍的诊断剂，包括：(a) 如权利要求 1 所定义的二硫代氨基甲酸铜衍生物的放射性铜络合物或二胺二醇席夫碱衍生物的放射性铜络合物；(b) 医药上可接受的稀释剂或载体。 根据本发明的诊断剂对靶组织具有良好的转移性，在缺氧部位具有还原反应亲和力，在非靶部位具有高稳定性，并能迅速从中消失。
• Positron emission capsule for image-guided proton therapy
  申请人：National Guard Health Affairs

  公开号：US10751431B2

  公开（公告）日：2020-08-25

  Multi-modal imaging capsule for image-guided proton beam therapy, consisting of a biocompatible polymer layer, 18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.

  用于图像引导质子束治疗的多模式成像胶囊，由生物相容性聚合物层、18O 富水和造影剂组成。在 X 射线、磁共振或超声成像的引导下，可将生物兼容胶囊插入肿瘤附近或内部。质子束照射后，胶囊会发射正电子，使 PET 检测器能够对肿瘤进行成像和跟踪。
• Methods for cell labeling and medical imaging
  申请人：MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

  公开号：US11534506B2

  公开（公告）日：2022-12-27

  Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89 Zr-Desferrioxamine-NCS labeling agent.

  本发明公开了用于体内成像的生物材料体外标记方法、生物材料体内标记方法、标记剂制备方法以及使用标记剂标记的生物材料对受试者进行体内成像的方法。在一个非限制性实例中，生物材料选自细胞，标记剂是 89 Zr-去铁胺-NCS 标记剂。
• Positron therapy of inflammation, infection and disease
  申请人：Dadachova Ekaterina

  公开号：US20060018827A1

  公开（公告）日：2006-01-26

  This invention provides methods for positron therapy of inflammation, infection and disease which comprise administering to a subject a positron emitter or an agent labeled with a positron emitter, wherein the positron emitter or agent binds to or is taken up by affected tissue or by cells at the site of affected tissue, infection or inflammation. The invention also provides kits, compositions and methods of making compositions comprising positron emitters for the treatment of inflammation, infection and disease.

  本发明提供了正电子治疗炎症、感染和疾病的方法，包括向受试者施用正电子发射器或用正电子发射器标记的药剂，其中正电子发射器或药剂与受影响组织或受影响组织、感染或炎症部位的细胞结合或被其吸收。本发明还提供了用于治疗炎症、感染和疾病的包含正电子发射体的试剂盒、组合物和组合物的制造方法。