丙酰基硫代胆碱 | 24578-90-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丙酰基硫代胆碱
• 中文别名: N,N,N-三甲基-2-(丙酰硫烷基)乙铵
• 英文名称: propionylthiocholine
• 英文别名: Propionylthiocholin；trimethyl(2-propanoylsulfanylethyl)azanium
• CAS: 24578-90-3
• 化学式: C₈H₁₈NOS
• 分子量: 176.303
• InChiKey: ILWCNQXVCCMVCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• VERFAHREN ZUR AKTIVITÄTSBESTIMMUNG VON CHOLINESTERASE
  申请人：SHINO-TEST LABORATORY CO., LTD.

  公开号：EP0067234A1

  公开（公告）日：1982-12-22

  Activity of cholinesterase in blood serum, which is important for diagnosis ofthe functional disturbance of liver, can be daily assayed according to a reaction rate determining method using an automatic analyzer, by reacting a blood serum sample with p-hydroxybenzoylcholine as a substrate in the presence of p-hydroxybenzoic acid hydroxylase.

  血清中胆碱酯酶的活性对诊断肝功能紊乱很重要，它可以通过自动分析仪，以对羟基苯甲酰基胆碱为底物，在对羟基苯甲酸羟化酶的作用下，使血清样本与对羟基苯甲酰基胆碱反应，根据反应速率测定法进行日常测定。
• Detection assays having chromogenic and nonchromogenic, hypocromogenic, bathochromogenic or hypsochromogenic substrates
  申请人：TECHNICON INSTRUMENTS CORPORATION (a New York corporation)

  公开号：EP0464388A1

  公开（公告）日：1992-01-08

  The invention relates to enzyme detection assay compositions and methods which have chromogenic and nonchromogenic, hypochromogenic, bathochromogenic or hypsochromogenic substrates. By using both chromogenic and nonchromogenic, hypochromogenic, bathochromogenic or hypsochromogenic substrates assay sensitivity can be controlled and the need for sample predilution eliminated. In one embodiment of the invention an assay for the estimation of serum cholinesterase activity is provided.

  本发明涉及酶检测化验组合物和方法，这些组合物和方法具有致色性和非致色性、低致色性、浴致色性或低次致色性底物。通过同时使用发色性和非发色性、低发色性、浴变色性或低变色性底物，可以控制检测灵敏度，并消除对样品预稀释的需要。在本发明的一个实施方案中，提供了一种用于估算血清胆碱酯酶活性的检测方法。
• Assay for serum cholinesterase acitivity
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0533283A1

  公开（公告）日：1993-03-24

  A dry analytical element for the determination of serum cholinesterase (CHE) activity is disclosed. The element analyses undiluted body fluids and employs butyrylthiocholine as the substrate for CHE. Butyrylthiocholine is hydrolyzed by serum cholinesterase and liberates butyric acid and thiocholine. The thiocholine liberated then reduces ferricyanide to ferrocyanide and the rate of change is measured by reflectance densitometry.

  本发明公开了一种用于测定血清胆碱酯酶（CHE）活性的干式分析元件。该分析元件可分析未稀释的体液，并采用丁酰硫代胆碱作为 CHE 的底物。丁酰硫代胆碱被血清胆碱酯酶水解后会释放出丁酸和硫代胆碱。释放出的硫代胆碱可将铁氰化物还原为铁氰化物，变化率可通过反射密度计测量。
• Method for measuring cholinesterase and method for distinguishing between liver cirrhosis and hepatitis
  申请人：Tosoh Corporation

  公开号：EP0738890A1

  公开（公告）日：1996-10-23

  The object of the present invention is to provide a method for discriminating between liver cirrhosis and chronic hepatitis by serodiagnosis using a simple enzyme immunoassay method without performing histopathological examinations by biopsy and so forth. The present invention discloses an enzyme immunoassay method for cholinesterase using a monoclonal antibody, a method for detecting Aleuria aurantia lectin-reactive cholinesterase using a monoclonal antibody and Aleuria aurantia lectin, and a method for discriminating between liver cirrhosis and chronic hepatitis on the basis of those results.

  本发明的目的是提供一种利用简单的酶免疫测定方法通过血清诊断鉴别肝硬化和慢性肝炎的方法，而无需进行活组织病理学检查等。 本发明公开了一种使用单克隆抗体检测胆碱酯酶的酶免疫测定方法，一种使用单克隆抗体和阿留申丝凝集素检测阿留申丝凝集素反应性胆碱酯酶的方法，以及一种根据这些结果区分肝硬化和慢性肝炎的方法。
• Stabilized cholinesterase substrate solution
  申请人：Roche Diagnostics GmbH

  公开号：EP1795607A1

  公开（公告）日：2007-06-13

  The present invention provides a stabilized cholinesterase substrate solution, wherein at least one substrate is stabilized by at least one species of a polar organic solvent. The present invention also relates to the use of a stabilized cholinesterase substrate solution, wherein at least one substrate is stabilized by at least one species of a polar organic solvent. Also within the scope of the present invention is a stabilized cholinesterase substrate solution for determining the activity of a cholinesterase in a sample, wherein at least one substrate is stabilized by at least one species of a polar organic solvent. Furthermore, the invention relates to a method for determining the activity of a cholinesterase in a sample, as well as a kit for determining the activity of a cholinesterase in a sample and a kit for conducting a method for determining the activity of a cholinesterase in a sample.

  本发明提供了一种稳定胆碱酯酶底物溶液，其中至少一种底物被至少一种极性有机溶剂稳定。本发明还涉及稳定胆碱酯酶底物溶液的用途，其中至少一种底物被至少一种极性有机溶剂稳定。本发明还涉及一种用于测定样品中胆碱酯酶活性的稳定胆碱酯酶底物溶液，其中至少一种底物被至少一种极性有机溶剂稳定。 此外，本发明还涉及一种测定样品中胆碱酯酶活性的方法，以及一种测定样品中胆碱酯酶活性的试剂盒和一种进行测定样品中胆碱酯酶活性的方法的试剂盒。

表征谱图