丙酰基胆碱 | 5072-54-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丙酰基胆碱
• 英文名称: Propionylcholine
• 英文别名: trimethyl(2-propanoyloxyethyl)azanium
• CAS: 5072-54-8
• 化学式: C8H18NO2+
• 分子量: 160.23
• InChiKey: VVQZRZCFJJZEKN-UHFFFAOYSA-N

物化性质

• 沸点：
  70 °C(Press: 8 Torr)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙酸 、 胆碱 以 水 为溶剂， 生成 丙酰基胆碱
  参考文献：
  名称：

  基于离子液体的贴剂配方，用于增强难溶性药物的透皮递送

  摘要：

  [显示省略]

  DOI：

  10.1016/j.molliq.2024.124184

文献信息

• CONTINUOUS PRODUCTION OF DMAEA QUATERNARY SALTS
  申请人：Fair Barbara E.

  公开号：US20110178327A1

  公开（公告）日：2011-07-21

  The invention provides a method of continuously producing high quality quaternized N,N-dialkylaminoethyl (meth)acrylates (DMAEA.MCQ) that has a long shelf life and which is stable in water. The method involves placing starting materials into a continuously stirred tank reactor in the presence of less than 6% water. This low amount of water causes two liquid phases to form and prevents unwanted side reactions. The denser liquid phase contains DMAEA.MCQ and the lighter phase contains the starting materials. Liquid from the denser phase is removed from a position where little of the lighter phase has been mixed in. The removed liquid then has any last traces of the starting materials reacted into DMAEA.MCQ and strips away any starting materials with a gas flow. The resulting liquid is high purity DMAEA.MCQ. Water can then safely be added to ease in the transport and use of the produced DMAEA.MCQ.

  该发明提供了一种连续生产高质量季铵化N，N-二烷氨基乙基（甲基）丙烯酸酯（DMAEA.MCQ）的方法，该方法具有长时间的货架寿命，并且在水中是稳定的。该方法涉及将起始材料置于连续搅拌槽反应器中，在存在少于6%的水的情况下。这种低水含量会导致形成两个液相，并防止不需要的副反应发生。更密集的液相含有DMAEA.MCQ，而较轻的液相含有起始材料。从几乎未混合较轻的液相的位置移除来自更密集相的液体。然后，将移除的液体中的任何最后痕迹的起始材料反应成DMAEA.MCQ，并使用气流带走任何起始材料。最终得到的液体是高纯度的DMAEA.MCQ。然后可以安全地添加水以便于运输和使用生产的DMAEA.MCQ。
• FERMENTED FOOD EXTRACT COMPOSITION
  申请人：Shinshu University

  公开号：US20170182108A1

  公开（公告）日：2017-06-29

  Provided is a fermented food extract that has a blood pressure-lowering action and is useful as a functional health food or pharmaceutical composition. This fermented food extract is obtained by: subjecting a fermented food, preferably a fermented fagopyrum esculentum lyophilisate, to acetone extraction; eluting the fermented fagopyrum esculentum acetone extract using a solid phase extract cartridge filled with a resin to which a phenyl group is bonded, with formic acid-containing water used as an eluent; and fractionating and purifying the eluate using a column (PFP column) filled with a carrier to which a pentafluorophenyl group is bonded, with formic acid/methanol-containing water used as a mobile phase. This functional health food or pharmaceutical composition contains said extract or at least a part thereof as an active ingredient.

  提供的是一种具有降血压作用并可用作功能性健康食品或药用组合物的发酵食品提取物。该发酵食品提取物的获取方法包括：将发酵食品（最好是发酵荞麦冻干物）经过丙酮提取；使用装有与苯基结合的树脂的固相萃取柱来洗脱发酵荞麦丙酮提取物，使用含甲酸的水作为洗脱剂；并使用装有与五氟苯基结合的载体的柱（PFP柱）来分馏和纯化洗脱物，使用含甲酸/甲醇的水作为流动相。这种功能性健康食品或药用组合物含有所述提取物或其至少一部分作为活性成分。
• [EN] ORGANIC NUTRIENT SALTS, METHODS OF PREPARATION AND USES<br/>[FR] SELS NUTRITIFS ORGANIQUES, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：BELLUS HEALTH INT LTD

  公开号：WO2010054485A1

  公开（公告）日：2010-05-20

  The current application relates to organic nutrient salts comprised of 3-amino-1-propanesulfonic acid (homotaurine) and an organic cationic component which contributes to the therapeutic and/or nutritional value of the salts. The application also relates to the method of preparing the organic nutrient salts and the use of the same as nutraceuticals for neuroprotection and for improving or protecting cognitive and memory functions.

  这项当前的申请涉及由3-氨基-1-丙磺酸（同牛磺酸）和一个有机阳离子组分组成的有机营养盐，该组分有助于盐的治疗和/或营养价值。该申请还涉及制备有机营养盐的方法以及将其用作神经保护的营养保健品，以改善或保护认知和记忆功能。
• Chain transfer agents for raft polymerization in aqueous media
  申请人：McCormick L. Charles

  公开号：US20070123670A1

  公开（公告）日：2007-05-31

  Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.

  通过产生分子量窄范围的手段合成的聚合物和共聚物可能具有不同于传统手段合成的聚合物的性质。然而，为了获得这种聚合物，聚合必须受到控制。一种受控聚合的类型是可逆加成-断裂链转移（RAFT）过程，具有活性聚合的特征。本发明揭示了一组二硫代酯和三硫代酯，适用于RAFT聚合的链转移剂。本发明还揭示了在水介质中进行的RAFT聚合。
• SYSTEM FOR THE CAPTURE AND RELEASE OF ACID GASES
  申请人：C-Capture Ltd.

  公开号：EP3488915A1

  公开（公告）日：2019-05-29

  The invention provides the use of an aqueous composition comprising at least one metal salt of an aliphatic carboxylic acid and at least one water-miscible non-aqueous solvent for the capture and release of CO2; wherein said at least one metal salt of an aliphatic carboxylic acid is initially present in said composition at a level of between 1M and 14M. The method offers a convenient and simple process which uses inexpensive consumables and offers significant advantages over the methods of the prior art.

  本发明提供了一种包含至少一种脂肪族羧酸金属盐和至少一种水溶性非水溶剂的水性组合物，用于捕获和释放二氧化碳；其中所述至少一种脂肪族羧酸金属盐在所述组合物中的初始含量为 1M 至 14M。与现有技术相比，该方法工艺简单方便，使用的消耗品价格低廉，具有显著优势。