N-methyl-2-(pyridin-2-yl)propan-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-methyl-2-(pyridin-2-yl)propan-2-amine
• 英文别名: Methyl[2-(pyridin-2-yl)propan-2-yl]amine；N-methyl-2-pyridin-2-ylpropan-2-amine
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: BNBIFCUPKFVQJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(吡啶-2-基)-2-丙胺 在 sodium hydride 作用下， 以 四氢呋喃 、 甲苯 、 mineral oil 为溶剂， 反应 8.25h， 生成 N-methyl-2-(pyridin-2-yl)propan-2-amine
  参考文献：
  名称：

  [EN] HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME
  [FR] COMPOSÉS HÉTÉROARYLÉS UTILISÉS COMME INHIBITEURS DE CXCR4, COMPOSITION ET PROCÉDÉ D'UTILISATION DE CEUX-CI

  摘要：

  本公开提供了Formula (I)的杂环芳基化合物，其制备方法，含有它们的药物组合物，以及它们在治疗源自或与CXCR4途径相关的疾病和障碍中的应用。

  公开号：

  WO2019060860A1

文献信息

• PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST
  申请人：Tanimoto Koichi

  公开号：US20090258867A1

  公开（公告）日：2009-10-15

  The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R 1 and R 2 are the same or different and each an optionally substituted aryl group etc, R 0 is hydrogen atom, an alkyl group etc, E is a group of the formula: —C(═O)— or —SO 2 —, R is a group of the following formula [i], [ii] or [iii] etc: Ring A is (a) a C 3-8 cycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, R 3 is an alkyl group optionally substituted by an alkylthio group, R 4 is hydrogen atom, an alkyl group etc, one of R A and R B is an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有CB1受体拮抗活性的吡唑并[1,5-a]嘧啶化合物，其化学式[I]如下：其中，R1和R2相同或不同，分别是可选取代的芳基等；R0是氢原子，烷基等；E是以下式子的基团：—C(═O)—或—SO2—；R是以下式子[i]、[ii]或[iii]等的基团：环A是(a)一个C3-8环烷基，可选地融合到苯环上，或(b)一个苯环；Q是单键或亚甲基基团；环B是一个4-7个成员的脂肪族杂环基团，该环基团通过其环碳原子与相邻的氮原子结合；X是硫原子等；R3是可选取代的烷基，可以是烷基硫基等；R4是氢原子，烷基等；RA和RB中的一个是烷基等，另一个是氢原子，烷基等，或其药学上可接受的盐。
• [EN] PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS<br/>[FR] PRÉPARATION DE DÉRIVÉS DE COMPOSÉS 1,2-DIAMINOHÉTÉROCYCLIQUES SUBSTITUÉS ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES
  申请人：AVELOS THERAPEUTICS INC

  公开号：WO2022260441A1

  公开（公告）日：2022-12-15

  This invention relates to compounds which are microtubule associated serine/threonine-like kinase (MASTL) inhibitors and the use of the compounds in the treatment of diseases and medical conditions mediated by MASTL, for example in the treatment of cancer and other target related diseases.

  本发明涉及一种微管相关丝氨酸/苏氨酸样激酶（MASTL）抑制剂化合物及其在治疗由MASTL介导的疾病和医学状况中的应用，例如在治疗癌症和其他相关疾病中的应用。
• Pyrazolo[1,5-a]pyrimidine compounds as CB1 receptor antagonists
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2520577A1

  公开（公告）日：2012-11-07

  The present invention provides pyrazolo[1,5-a]pyrimidine compounds and pharmaceutically acceptable salts thereof having CB1 receptor-antagonizing activity. These compounds, and compositions comprising the same, are hence useful in the treatment of a wide range of conditions and diseases.

  本发明提供了具有 CB1 受体拮抗活性的吡唑并[1,5-a]嘧啶化合物及其药学上可接受的盐类。这些化合物及其组合物可用于治疗多种病症和疾病。
• HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME
  申请人：CGeneTech (Suzhou, China) Co., Ltd.

  公开号：EP3687540A1

  公开（公告）日：2020-08-05
• Fungicide 2-pyridyl-methylene-carboxamide derivatives
  申请人：Gary Stephanie

  公开号：US20100010048A1

  公开（公告）日：2010-01-14

  The present invention relates to 2-pyridyl-methylene-carboxamide derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions: