乌比新定 | 26070-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 乌比新定
• 英文名称: ubisindine
• 英文别名: 2-[2-(diethylamino)ethyl]-3-phenyl-3H-isoindol-1-one
• CAS: 26070-78-0
• 化学式: C₂₀H₂₄N₂O
• 分子量: 308.423
• InChiKey: ZNYIBRGXWAWBAL-UHFFFAOYSA-N

物化性质

• 熔点：
  63-64 °C(Solv: ligroine (8032-32-4))
• 沸点：
  442.2±45.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

文献信息

• [EN] UNIVERSAL METHYLATION PROFILING METHODS<br/>[FR] PROCÉDÉS UNIVERSELS D'ÉTABLISSEMENT DE PROFILS DE MÉTHYLATION
  申请人：UNIV COLUMBIA

  公开号：WO2016100864A1

  公开（公告）日：2016-06-23

  The present invention provides a method of determining whether cytosine residues present at a predetermined positions within a singl strand of a double stranded DNA of known sequence are methylated as well as compounds for carrying out this method. The present invention also provides a process of producing a derivative of a double-stranded DNA comprising contacting the double-stranded DNA with a CpG methyltransferase and an S-adenosylmethionine analog.

  本发明提供了一种确定已知序列的双链DNA中单链的特定位置是否存在甲基化的方法，以及用于执行该方法的化合物。本发明还提供了一种生产双链DNA衍生物的过程，包括将双链DNA与CpG甲基转移酶和S-腺苷甲硫氨酸类似物接触。
• [EN] UNIVERSAL METHYLATION PROFILING METHODS<br/>[FR] PROCÉDÉS UNIVERSELS DE PROFILAGE DE LA MÉTHYLATION
  申请人：UNIV COLUMBIA

  公开号：WO2014204861A1

  公开（公告）日：2014-12-24

  The present invention provides a compound having the adenosylmethionine structure, wherein the sulfur atom of the methionine moiety is modified with alkene or succinimide groups, wherein R1, R2 and R3 are independently H, alkyl, aryl, C(0)NH2, C(0)R', CN, N02, C (O)R', S(0),NHR'; wherein X is 0 or NR'; wherein R' is H, alkyl or aryl; and wherein n is an integer from 1 to 8, with the proviso that, when substituent is a propene derivative, and n is 1, at least one of R1, R2, or R3 is other than H.

  本发明提供了一种具有腺苷甲硫氨酸结构的化合物，其中蛋氨酸部分的硫原子经过烯烃或琥珀酰亚胺基团修饰，其中R1、R2和R3独立地为H、烷基、芳基、C(0)NH2、C(0)R'、CN、NO2、C(O)R'、S(0)、NHR'；其中X为0或NR'；其中R'为H、烷基或芳基；n为1至8之间的整数，但当取代基为丙烯衍生物且n为1时，至少有一个R1、R2或R3不为H。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Isoindolin-1-one derivative and antiarrhythmic agent
  申请人：KYOWA HAKKO KOGYO KABUSHIKI KAISHA

  公开号：EP0273401A1

  公开（公告）日：1988-07-06

  Isoindolin-1-one compounds represented by the following formula (I); wherein n represents an integer of 1 to 6; m represents 0 or 1; R1, R2 and R3 are each independently hydrogen or lower alkyl, and when m is 1, R, and one of R2 and R3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): (wherein Rs and R7 are each independently hydrogen, lower alkyl or lower alkanoyl); R4 and R5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a phrarmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.

  由下式（I）代表的异吲哚啉-1-酮化合物； 其中 n 代表 1 至 6 的整数；m 代表 0 或 1；R1、R2 和 R3 各自独立地为氢或低级烷基，当 m 为 1 时，R 以及 R2 和 R3 中的一个可在 N 原子上形成五元环或六元环；X 代表氢或羟基；Ar 代表萘基、吡啶基或由式（II）代表的取代苯基；Ar 和 X 可形成内酯环； [其中 Y 代表羧基、低级烷氧基羰基、氨基甲酰基、N,N-低级烷基取代的氨基甲酰基或由式（III）代表的氨基： (其中 Rs 和 R7 各自独立地为氢、低级烷基或低级烷酰基）；R4 和 R5 各自独立地为氢、低级烷基、氰基或卤素]}或其短链可接受的酸加成盐或金属盐具有极佳的抗心律失常活性。
• Methods and compositions for assessing CpG methylation
  申请人：Agilent Technologies, Inc.

  公开号：EP1589118A2

  公开（公告）日：2005-10-26

  Methods and compositions for assessing CpG island methylation are provided. Specifically, the invention provides an unstructured nucleic acid (UNA) oligonucleotide that base pairs with, i.e., hybridizes to, CpG islands. The subject oligonucleotide may be present in an array, and find use in methods for evaluating methylation of CpG islands in cells. Kits and computer programming for use in practicing the subject methods are also provided.

  本发明提供了评估 CpG 岛甲基化的方法和组合物。具体来说，本发明提供了一种非结构化核酸（UNA）寡核苷酸，它能与 CpG 岛碱基配对，即与 CpG 岛杂交。该寡核苷酸可存在于阵列中，并可用于评估细胞中 CpG 岛甲基化的方法。此外，还提供了用于实施上述方法的试剂盒和计算机程序。