naphthalene-1-sulfonic acid dibutylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalene-1-sulfonic acid dibutylamide
• 英文别名: N,N-dibutylnaphthalene-1-sulfonamide
• 化学式: C₁₈H₂₅NO₂S
• 分子量: 319.468
• InChiKey: BOKZEYLMVZFSMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-萘磺酰氯 、 二正丁胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 naphthalene-1-sulfonic acid dibutylamide
  参考文献：
  名称：

  METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND

  摘要：

  这项发明提供了一种有效的方法，可以降低载脂蛋白E的表达，并增加至少一种LDL受体蛋白或AbcA1蛋白的表达，包括选择表达apoE和至少一种LDL受体蛋白或AbcA1蛋白的哺乳动物细胞，将哺乳动物细胞与通式（I）或通式（II）的化合物的有效量接触，其量足以降低apoE的表达并增加哺乳动物细胞中至少一种LDL受体蛋白或AbcA1蛋白的表达。

  公开号：

  US20180093960A1

文献信息

• Ionic liquid enabled sulfamoylation of arenes: an ambient, expeditious and regioselective protocol for aryl sulfonamides
  作者：Prashant U. Naik、Jitendra R. Harjani、Susheel J. Nara、Manikrao M. Salunkhe

  DOI：10.1016/j.tetlet.2003.12.132

  日期：2004.2.23

  The ionic liquid, 1-butyl-3-methylimidazolium chloroaluminate, [bmim]Cl.AlCl3, N=0.67 mediated syntheses of aromatic sulfonamides via electrophilic substitution of arenes is reported. The protocol serves as a distinctly expeditious and ambient route towards the syntheses of these pharmaceutically useful compounds, yielding quantitative conversions at room temperature within 5-30 min in most of the cases. The Lewis acidity and molar stoichiometry of the ionic liquid influences the extent of conversion. The method has been used for the syntheses of a diverse range of sulfonamides by variation of arenes and sulfamoyl chlorides. With monosubstituted benzenes, the protocol offers an added advantage of exclusive selectivity towards the formation of para substituted sulfonamides over the ortho products. (C) 2004 Elsevier Ltd. All rights reserved.
• KATAOKA, HIROYUKI;OKAZAKI, TSUNEKI;MAKITA, MASAMI, J. CHROMATOGR., 473,(1989) N, C. 276-280
  作者：KATAOKA, HIROYUKI、OKAZAKI, TSUNEKI、MAKITA, MASAMI

  DOI：——

  日期：——
• METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND
  申请人：California State University, Fresno

  公开号：US20180093960A1

  公开（公告）日：2018-04-05

  This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.

  这项发明提供了一种有效的方法，可以降低载脂蛋白E的表达，并增加至少一种LDL受体蛋白或AbcA1蛋白的表达，包括选择表达apoE和至少一种LDL受体蛋白或AbcA1蛋白的哺乳动物细胞，将哺乳动物细胞与通式（I）或通式（II）的化合物的有效量接触，其量足以降低apoE的表达并增加哺乳动物细胞中至少一种LDL受体蛋白或AbcA1蛋白的表达。