N-[(3R)-3-[[3-[[(2R)-3-hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[(3R)-3-[[3-[[(2R)-3-hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
• 化学式: C₁₃H₂₈N₄O₂
• 分子量: 272.391
• InChiKey: BPNZYADGDZPRTK-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.67
• 重原子数：
  19.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  89.24
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  二甲基丙二醛 在 盐酸 、 sodium tetrahydroborate 、 羟胺 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 N-[(3R)-3-[[3-[[(2R)-3-hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
  参考文献：
  名称：

  Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties

  摘要：

  Tc-D,D- and Tc-L,L-HMPAO were synthesized. The stability of Tc-D,D- and Tc-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higher than the D,D- and d,1-isomer in rats. Delayed studies shows that TC-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00557-0

文献信息

• Jurisson; Schlemper; Troutner, Inorganic Chemistry, 1986, vol. 25, # 4, p. 543 - 549
  作者：Jurisson、Schlemper、Troutner、Canning、Nowotnik、Neirinckx

  DOI：——

  日期：——
• Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties
  作者：Hueisch-Jy Ding、Ying-Fong Huang、Cherng-Chyi Tzeng、Li-Mei Wei、Si-Jung Yeh

  DOI：10.1016/s0960-894x(99)00557-0

  日期：1999.11

  Tc-D,D- and Tc-L,L-HMPAO were synthesized. The stability of Tc-D,D- and Tc-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higher than the D,D- and d,1-isomer in rats. Delayed studies shows that TC-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer. (C) 1999 Elsevier Science Ltd. All rights reserved.