4-(bis(tert-butylthio)methyl)-2-methoxyphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(bis(tert-butylthio)methyl)-2-methoxyphenol
• 英文别名: 4-[Bis(tert-butylsulfanyl)methyl]-2-methoxyphenol；4-[bis(tert-butylsulfanyl)methyl]-2-methoxyphenol
• 化学式: C₁₆H₂₆O₂S₂
• 分子量: 314.513
• InChiKey: ZKMOLRHUYPFRLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  香草醛 、 叔丁基硫醇 在 graphene oxide 作用下， 以 neat (no solvent) 为溶剂， 反应 5.0h， 以93%的产率得到4-(bis(tert-butylthio)methyl)-2-methoxyphenol
  参考文献：
  名称：

  Graphene oxide (GO)-catalyzed chemoselective thioacetalization of aldehydes under solvent-free conditions

  摘要：

  An efficient method for the synthesis of open chain, cyclic, and unsymmetrical dithioacetals from aryl/hetero-aryl/aliphatic aldehydes is described. The reaction is performed using graphene oxide (GO) as the catalyst under solvent-free and aerobic conditions. High chemoselectivity is observed in the reaction as aryl/alkyl ketones do not give thioketals under the condition. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.043

文献信息

• Graphene oxide (GO)-catalyzed chemoselective thioacetalization of aldehydes under solvent-free conditions
  作者：Babli Roy、Debasish Sengupta、Basudeb Basu

  DOI：10.1016/j.tetlet.2014.10.043

  日期：2014.11

  An efficient method for the synthesis of open chain, cyclic, and unsymmetrical dithioacetals from aryl/hetero-aryl/aliphatic aldehydes is described. The reaction is performed using graphene oxide (GO) as the catalyst under solvent-free and aerobic conditions. High chemoselectivity is observed in the reaction as aryl/alkyl ketones do not give thioketals under the condition. (C) 2014 Elsevier Ltd. All rights reserved.