N'-(4-hydroxy-3-methoxybenzylidene)-2-phenoxypropanehydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N'-(4-hydroxy-3-methoxybenzylidene)-2-phenoxypropanehydrazide
• 英文别名: N-[(4-hydroxy-3-methoxyphenyl)methylideneamino]-2-phenoxypropanamide
• 化学式: C₁₇H₁₈N₂O₄
• 分子量: 314.341
• InChiKey: OOXAHMQGJFFVEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  香草醛 、 2-苯氧基丙肼 在 盐酸 作用下， 以 水 为溶剂， 反应 6.0h， 以90%的产率得到N'-(4-hydroxy-3-methoxybenzylidene)-2-phenoxypropanehydrazide
  参考文献：
  名称：

  Synthesis of Potential Biologically Active Compounds Based on Aryloxy- and Arylaminopropanehydrazides

  摘要：

  New derivatives of a number of aryloxy and arylaminopropanehydrazides were synthesized. Their heterocyclization under the action of carbon disulfide and potassium hydroxide and subsequent alkylation of the resulting 2-thioxo-1,3,4-oxadiazole ring, the corresponding S-substituted products were obtained. The reaction of the starting hydrazides with arylaldehydes and pentane-2,4-dione afforded theirN '-arylidene and N '-(4-oxopentan-2-ylidene) derivatives. In preliminary laboratory tests, the synthesized compounds showed a pronounced stimulating effect on plant growth. Their activity was 44-95% compared with heteroauxin.

  DOI：

  10.1134/s1070363220070014

文献信息

• Synthesis of Potential Biologically Active Compounds Based on Aryloxy- and Arylaminopropanehydrazides
  作者：T. A. Gomktsyan、R. S. Shainova、A. V. Karapetyan、A. P. Yengoyan

  DOI：10.1134/s1070363220070014

  日期：2020.7

  New derivatives of a number of aryloxy and arylaminopropanehydrazides were synthesized. Their heterocyclization under the action of carbon disulfide and potassium hydroxide and subsequent alkylation of the resulting 2-thioxo-1,3,4-oxadiazole ring, the corresponding S-substituted products were obtained. The reaction of the starting hydrazides with arylaldehydes and pentane-2,4-dione afforded theirN '-arylidene and N '-(4-oxopentan-2-ylidene) derivatives. In preliminary laboratory tests, the synthesized compounds showed a pronounced stimulating effect on plant growth. Their activity was 44-95% compared with heteroauxin.