1-butoxy-3-(phenylamino)propan-2-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-butoxy-3-(phenylamino)propan-2-ol
• 英文别名: 1-anilino-3-butoxy-2-propanol；1-Anilino-3-butoxypropan-2-ol
• 化学式: C₁₃H₂₁NO₂
• 分子量: 223.315
• InChiKey: IELSEKLNWHVOOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丁基缩水甘油醚 、 苯胺 在 bismuth(lll) trifluoromethanesulfonate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以85%的产率得到1-butoxy-3-(phenylamino)propan-2-ol
  参考文献：
  名称：

  Bismuth(III) trifluoromethanesulfonate and trifluoroacetate as convenient and efficient catalysts for regio- and chemoselective ring opening of epoxides in reactions with anilines

  摘要：

  三氟甲磺酸铋（III）和三氟乙酸铋是环氧化物与取代苯胺反应中环氧乙烷开环的高效实用催化剂。这些反应的特点是化学选择性高，产物收率高甚至极高。

  DOI：

  10.1007/s11178-005-0016-2

文献信息

• Bismuth(III) trifluoromethanesulfonate and trifluoroacetate as convenient and efficient catalysts for regio- and chemoselective ring opening of epoxides in reactions with anilines
  作者：A. R. Khosropour、M. M. Khodaei、K. Ghozati

  DOI：10.1007/s11178-005-0016-2

  日期：2004.9

  Bismuth(III) trifluoromethanesulfonate and trifluoroacetate are highly efficient and practical catalysts for oxirane ring opening in reactions of epoxides with substituted anilines. The reactions are characterized by high chemoselectivity and good to excellent yields of the products.

  三氟甲磺酸铋（III）和三氟乙酸铋是环氧化物与取代苯胺反应中环氧乙烷开环的高效实用催化剂。这些反应的特点是化学选择性高，产物收率高甚至极高。
• Bi(OTf)₃- and Bi(TFA)₃-Catalyzed Ring Opening of Epoxides with Anilines under Microwave Irradiation
  作者：Ahmad R. Khosropour、Mohammad M. Khodaei、Kazem Ghozati

  DOI：10.1246/cl.2004.304

  日期：2004.3

  A facile and environmentally friendly methodology for ring opening of epoxides with anilines has been developed in the presence of catalytic amounts of bismuth (III) triflate or bismuth (III) trifluoroacetate using microwave-assisted heating. The ease of this procedure allowed preparation of the β-aminoalcohols quickly and efficiently.

  在催化量的三氟乙酸铋（III）或三氟乙酸铋（III）存在下，利用微波辅助加热，开发出了一种用苯胺进行环氧化物开环的简便而环保的方法。这种方法简单易行，可以快速高效地制备 β-氨基醇。
• A powerful, practical and chemoselective synthesis of 2-anilinoalkanols catalyzed by Bi(TFA)3 or Bi(OTf)3 in the presence of molten TBAB
  作者：Mohammd M. Khodaei、Ahmad R. Khosropour、Kazem Ghozati

  DOI：10.1016/j.tetlet.2004.02.139

  日期：2004.4

  A facile and efficient synthesis of β-amino alcohols by ring opening of epoxides with anilines in good to excellent yields in the presence of catalytic amounts of Bi(TFA)3 or Bi(OTf)3 via the use of molten tetrabutylammonium bromide (TBAB) as an ionic liquid is described. In addition, the observed chemoselectivity can be considered as a noteworthy advantage of this method.

  在存在催化量的Bi（TFA）3或Bi（OTf）3的情况下，通过使用熔融四丁基溴化铵（TBAB），通过与苯胺的环氧化物与苯胺的开环，轻松高效地合成β-氨基醇描述了离子液体。另外，观察到的化学选择性可以认为是该方法的显着优点。
• Hβ zeolite: An Efficient and Reusable Catalyst for Ring-Opening of Epoxides with Amines Under Microwave Irradiation
  作者：Rukhsana I. Kureshy、Santosh Agrawal、Manish Kumar、Noor-ul H. Khan、Sayed H. R. Abdi、Hari C. Bajaj

  DOI：10.1007/s10562-009-0237-z

  日期：2010.2

  A solvent-free protocol for the synthesis of beta-amino alcohols (Yield, up to 94%) is demonstrated by the ring-opening reactions of meso and terminal epoxides with aromatic amines using H beta zeolite as catalyst under microwave irradiation. The catalytic system is 80 times faster than the reaction conducted at RT with six times catalyst recyclability.
• 10.1002/1099-0690(200111)2001:21<4149::aid-ejoc4149<3.0.co;2-r
  作者：Curini, Massimo、Epifano, Francesco、Marcotullio, Maria Carla、Rosati, Ornelio

  DOI：10.1002/1099-0690(200111)2001:21<4149::aid-ejoc4149<3.0.co;2-r

  日期：——