乙基5-苯基-2-(三氟甲基)-3-糠酸酯 | 672930-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 乙基5-苯基-2-(三氟甲基)-3-糠酸酯
• 英文名称: ethyl 5-phenyl-2-(trifluoromethyl)furan-3-carboxylate
• CAS: 672930-51-7
• 化学式: C₁₄H₁₁F₃O₃
• 分子量: 284.235
• InChiKey: WCYGZXKPRGOTJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2'-溴苯乙酮 在 sodium hydride 、 对甲苯磺酸 作用下， 以 乙二醇二甲醚 、 水 、 甲苯 为溶剂， 反应 8.5h， 生成 乙基5-苯基-2-(三氟甲基)-3-糠酸酯
  参考文献：
  名称：

  EP1535915

  摘要：

  公开号：

文献信息

• Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes
  作者：Wei Wen Tan、Naohiko Yoshikai

  DOI：10.1021/acs.joc.6b00904

  日期：2016.7.1

  We report herein copper(II)-catalyzed cyclization reactions of silyl enol ethers derived from methyl ketones with α-diazo-β-ketoesters or α-diazoketones to afford 2-siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditions. The former cyclization products serve as versatile 1,4-diketone surrogates, allowing facile preparation of 2,3,5-trisubstituted furans

  我们在本文中报道了铜（II）催化的甲基酮衍生的甲硅烷基烯醇醚与α-重氮-β-酮酸酯或α-二氮酮的环化反应，从而提供2-siloxy-2,3-dihydrofuran衍生物或2,3,5-三取代的呋喃，分别在温和的条件下。以前的环化产品可以用作通用的1,4-二酮替代物，从而可以轻松制备2,3,5-三取代的呋喃，吡咯和噻吩。
• Furan Synthesis via Triplet Sensitization of Acceptor/Acceptor Diazoalkanes
  作者：Siqi Zhu、Fang Li、Claire Empel、Sripati Jana、Chao Pei、Rene M. Koenigs

  DOI：10.1002/adsc.202200654

  日期：2022.9.20

  reaction of acceptor/acceptor diazoalkanes with terminal alkynes. Experimental and computational studies suggest the formation of a key triplet carbene intermediate that undergoes an addition reaction to the alkyne followed by cyclization to give furan heterocycles (31 to 90% yield). This reaction was studied with a broad range of alkynes and acceptor/acceptor diazoalkanes and now provides access to furans

  在此，我们报道了受体/受体重氮烷烃与末端炔烃的光催化反应。实验和计算研究表明形成了一个关键的三线态卡宾中间体，该中间体与炔烃发生加成反应，然后环化得到呋喃杂环（31% 至 90% 的产率）。该反应用广泛的炔烃和受体/受体重氮烷烃进行了研究，现在可以在温和的反应条件下获得呋喃。
• FURAN OR THIOPHENE DERIVATIVE AND MEDICINAL USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1535915A1

  公开（公告）日：2005-06-01

  The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or -S(O)n- (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, -S(O)m-, -C(=O)-N(R3)- or -N(R3)-C(=O)- (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

  本发明提供了一种由式（I）表示的化合物： [其中 R 为任选取代的烃基或任选取代的杂环基，p 为 0、1 或 2，当 p 为 2 时，每个 R 可以相同或不同，R1 为氢原子或任选取代的烃基，R2 为任选取代的芳香基、环 A 是任选取代的单环芳香环或任选取代的双环芳香融合环，X1 是氧原子或硫原子，X2 是键、氧原子或 -S(O)n- （其中 n 是 0、1 或 2），Y 是键、氧原子、-S(O)m-、-R3是氢原子、任选取代的烃基或任选取代的杂环基，m是0、1或2），M1、M2和M3可以相同或不同，各自独立地是键或任选取代的二价脂族烃基、和 M4 是任选取代的二价脂族烃基]或其盐，可用作脂质代谢异常、动脉硬化疾病及其后遗症、糖尿病等的预防和/或治疗剂。
• Furan or thiopene derivative and medicinal use thereof
  申请人：Hamamura Kazumasa

  公开号：US20060100261A1

  公开（公告）日：2006-05-11

  The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R 1 is a hydrogen atom or an optionally substituted hydrocarbon group, R 2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X 1 is an oxygen atom or a sulfur atom, X 2 is a bond, an oxygen atom or —S(O) n — (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O) m —, —C(═O)—N(R 3 )— or —N(R 3 )—C(═O)— (R 3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M 1 , M 2 and M 3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M 4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

  本发明提供了一种由式（I）表示的化合物： [其中 R 为任选取代的烃基或任选取代的杂环基，p 为 0、1 或 2，当 p 为 2 时，每个 R 可以相同或不同，R 1 是氢原子或任选取代的烃基，R 2 是任选取代的芳香基团，环 A 是任选取代的单环芳香环或任选取代的双环芳香融合环，X 1 是氧原子或硫原子，X 2 是键、氧原子或 -S(O) n - 其中 n 为 0、1 或 2），Y 为键、氧原子、-S(O) m -、-C(═O)-N(R 3 )-或-N(R 3 )-C(═O)-(R 3 是氢原子、任选取代的烃基或任选取代的杂环基，且 m 是 0、1 或 2），M 1 , M 2 和 M 3 可以相同或不同，且各自独立地为键或任选取代的二价脂族烃基，以及 M 4 是任选取代的二价脂族烃基]或其盐，可用作脂质代谢异常、动脉硬化疾病及其后遗症、糖尿病等的预防和/或治疗剂。
• Rh2(OAc)4 catalyzed formation of fluorine-containing polysubstituted furans from diazocompounds and aromatic alkynes
  作者：Wan Pang、Shifa Zhu、Yong Xin、Huanfeng Jiang、Shizheng Zhu

  DOI：10.1016/j.tet.2009.12.015

  日期：2010.2

  A new building block strategy for the synthesis Of fluorine-containing 1,2,4-trisubstituted furan was reported The 1,2,4-trisubstituted furan was constructed through [3+2] cycloaddition reaction of fluoroacetyl-containing diazocompound and aromatic alkyne, catalyzed by Rh-2(OAc)(4) (C) 2009 Elsevier Ltd All rights reserved