L-carnitine calcium fumarate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: L-carnitine calcium fumarate
• 英文别名: calcium;(E)-but-2-enedioate;(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate
• 化学式: C₄H₂O₄*C₇H₁₅NO₃*Ca
• 分子量: 315.336
• InChiKey: KTUYNMKITNGXTP-UNKACTGFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.14
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  141
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  calcium hydroxide 、 左旋肉碱 、 富马酸 以 水 为溶剂， 反应 2.0h， 生成 L-carnitine calcium fumarate
  参考文献：
  名称：

  Non-hygroscopic L-carnitine salts

  摘要：

  提供了稳定且非吸湿性的有机酸L-肉碱盐，每种盐都以真正的复合盐形式存在，其化学式如下：其中Z为乙酸盐、丙酸盐或丁酸盐。此外，还提供了制备这些化合物的方法，以及将这些化合物用作营养中L-肉碱和钙离子的来源，或者用作具有治疗药理活性的药用活性成分的用途。

  公开号：

  US20080234371A1

文献信息

• L-CARNITINE CALCIUM FUMARATE, PREPARATION METHOD AND APPLICATION FOR THE SAME
  申请人：Yuan Xueliang

  公开号：US20090281183A1

  公开（公告）日：2009-11-12

  L-carnitine calcium fumarate and its preparation and applications are disclosed in the present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the L-carnitine calcium fumarate as proposed having the advantages of being non-hygroscopic, stable in chemical property, and suitable for oral administration. A preparing method is as follow: fumaric acid is suspended in water and calcium base is added. The resulting mixture is heated up to 70˜90° C. and kept under stirring for 2˜8 hours, and then concentrated under reduced pressure. The resulting dried substance is added into ethanol, and the mixture is vigorously stirred. The inner salt of L-carnitine is added, and the mixture is reacted for 1-6 hours at 60˜70° C. and then cooled for 2˜8 hours. L-carnitine calcium fumarate is obtained by filtration.

  本发明公开了L-肉碱钙富马酸盐及其制备和应用。该L-肉碱钙富马酸盐具有良好的水溶性，以及比相应的内盐更好和更强的营养和治疗功能，具有非吸湿性、化学稳定性好、适合口服等优点。其制备方法如下：将富马酸悬浮于水中，加入钙基，将混合物加热至70~90℃并搅拌2~8小时，然后在减压下浓缩。将得到的干燥物质加入乙醇中，并 vigorously 搅拌。加入L-肉碱内盐，混合物在60~70℃反应1-6小时，然后冷却2~8小时。通过过滤得到L-肉碱钙富马酸盐。
• L-carnitine calcium fumarate, preparation method and application for the same
  申请人：Yuan Xueliang

  公开号：US20110245537A1

  公开（公告）日：2011-10-06

  L-carnitine calcium fumarate and its preparation and applications are disclosed in the present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the L-carnitine calcium fumarate as proposed having the advantages of being non-hygroscopic, stable in chemical property, and suitable for oral administration. A preparing method is as follow: fumaric acid is suspended in water and calcium base is added. The resulting mixture is heated up to 70˜90° C. and kept under stirring for 2˜8 hours, and then concentrated under reduced pressure. The resulting dried substance is added into ethanol, and the mixture is vigorously stirred. The inner salt of L-carnitine is added, and the mixture is reacted for 1˜6 hours at 60˜70° C. and then cooled for 2˜8 hours. L-carnitine calcium fumarate is obtained by filtration.

  本发明揭示了L-肉碱钙富马酸盐及其制备和应用。该L-肉碱钙富马酸盐具有良好的水溶性，以及比相应的内盐更好和更强的营养和治疗功能，具有非吸湿性、化学性质稳定和适宜口服的优点。其制备方法如下：将富马酸悬浮在水中，加入钙基，将得到的混合物加热至70˜90℃，并在搅拌下保持2˜8小时，然后在减压下浓缩。所得到的干燥物质加入乙醇中，强烈搅拌混合。加入L-肉碱的内盐，将混合物在60˜70℃下反应1˜6小时，然后冷却2˜8小时，通过过滤得到L-肉碱钙富马酸盐。