N,N-bis(methoxymethyl)-N-propylamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-bis(methoxymethyl)-N-propylamine
• 英文别名: N,N-bis(methoxymethyl)propan-1-amine
• 化学式: C₇H₁₇NO₂
• 分子量: 147.217
• InChiKey: YLJNDFZLPMJJEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  吡咯 、 N,N-bis(methoxymethyl)-N-propylamine 在 nickel(II) chloride hexahydrate 作用下， 以 吡啶 为溶剂， 反应 6.0h， 以37%的产率得到3-propyl-3,8-diazabicyclo[3.2.1]octa-1(7),5-diene
  参考文献：
  名称：

  过渡金属催化的吡咯和吲哚的C，C-和C，N-环氨基甲基化反应

  摘要：

  在[Ni（Py）4 Cl 2 ]·0.76H 2 O或NiCl 2 ·6H 2 O催化剂存在下，用双（甲氧基甲基）烷基胺或烷基（苯基）胺与低聚甲醛的混合物催化吡咯的环氨基甲基化吡咯环的2和5。在ZrOCl 2 ·8H 2 O催化剂存在下，吲哚的环氨基甲基化可在位置1和3处有效完成。当咔唑在ZrOCl 2 ·8H 2 O催化剂存在下用双（甲氧基甲基）烷基胺处理时，将其转化为N-氨基甲基化产物– N -[（9 H-咔唑-9-基）甲基] -N-（甲氧基甲基）烷基胺。

  DOI：

  10.1007/s10593-018-2299-6
• 作为产物：
  描述：

  正丙胺 、 聚合甲醛 以 甲醇 为溶剂， 反应 3.0h， 生成 N,N-bis(methoxymethyl)-N-propylamine
  参考文献：
  名称：

  一锅催化合成2,7-双取代的4,9（10）-二甲基-2,3a，5a，7,8a，10a-六氮杂过氢吡啶

  摘要：

  已经开发了用于合成2,7-双取代的4,9（10）-二甲基-2,3a，5a，7,8a，10a-六氮杂过氢吡啶的催化方法。该结构是基于1 H和13 C NMR光谱，2D NMR（HSQC，HMBC，COSY，NOESY）技术，MALDI TOF / TOF光谱和X射线衍射数据确定的。初步筛选了合成的六氮杂氢吡啶类化合物的抗菌活性。

  DOI：

  10.1016/j.tet.2017.10.048

文献信息

• Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes
  作者：Elena B. Rakhimova、Victor Yu. Kirsanov、Elena V. Tret'yakova、Leonard M. Khalilov、Askhat G. Ibragimov、Lilya U. Dzhemileva、Vladimir A. D'yakonov、Usein M. Dzhemilev

  DOI：10.1039/d0ra03209c

  日期：——

  Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3bR*,7aR*,10bR*,14aR*-cis-14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes with pronounced antitumor activity have been developed.

  催化方法已开发用于合成以前未知的具有显著抗肿瘤活性的2,9-二取代3bR*,7aR*,10bR*,14aR*-顺式-14c,14d-四氢-2,3a,7b,9,10a,14b-六氮杂二苯并四环烯。
• One-pot catalytic synthesis of 2,7- bis -substituted 4,9(10)-dimethyl-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes
  作者：Elena B. Rakhimova、Victor Yu. Kirsanov、Ekaterina S. Meshcheryakova、Leonard M. Khalilov、Boris I. Kutepov、Askhat G. Ibragimov、Usein M. Dzhemilev

  DOI：10.1016/j.tet.2017.10.048

  日期：2017.12

  7-bis-substituted 4,9(10)-dimethyl-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes have been developed. The structure was established on the basis of 1H and 13C NMR spectra, 2D NMR (HSQC, HMBC, COSY, NOESY) techniques, MALDI TOF/TOF spectra, and X-ray diffraction data. Primary screening of the synthesized hexaazaperhydropyrenes for antimicrobial activity was performed.

  已经开发了用于合成2,7-双取代的4,9（10）-二甲基-2,3a，5a，7,8a，10a-六氮杂过氢吡啶的催化方法。该结构是基于1 H和13 C NMR光谱，2D NMR（HSQC，HMBC，COSY，NOESY）技术，MALDI TOF / TOF光谱和X射线衍射数据确定的。初步筛选了合成的六氮杂氢吡啶类化合物的抗菌活性。
• An efficient catalytic method for the synthesis of 2,7-dialkyl-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes
  作者：Elena B. Rakhimova、Rinat A. Ismagilov、Ekaterina S. Meshcheryakova、Leonard M. Khalilov、Askhat G. Ibragimov、Usein M. Dzhemilev

  DOI：10.1016/j.tetlet.2014.09.122

  日期：2014.11

  An efficient method for the synthesis of 2,7-dialky1-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes in high yields (up to 95%) via the intermolecular cyclization of 1,4,5,8-tetraazadecalin with N,N-bis(methoxy-methyl)-N-alkylamines in the presence of SmCI3 center dot 6H(2)O as the catalyst has been developed. (C) 2014 Elsevier Ltd. All rights reserved.
• PHOSPHORUS NITROGEN FLAME RETARDANT, METHOD THEREOF AND MATERIAL COMPRISING THE SAME
  申请人：ZHOU Chongfu

  公开号：US20220127533A1

  公开（公告）日：2022-04-28

  Provided are phosphorus nitrogen flame retardants represented by Formula III, a method of preparing the flame retardants without using any solvent, and various materials comprising the flame retardants. Rb and Rc are independently of each other selected from hydrogen, substituted or unsubstituted alkyl such as C1-C18 alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic alkyl, substituted or unsubstituted heterocycles, substituted or unsubstituted aryl such as C6˜C18 aryl, substituted or unsubstituted heteroaryl such as C3˜C18 heteroaryl, and acyl radical. The invention exhibits numerous technical merits such as excellent flame retardant efficacy, good compatibility with polymers, lower migration to material surface, excellent hydrolysis resistance, low smoke and low toxicity during burning, simpler preparation process, fewer by-products, shorter reaction time, higher yield, and no environmental impact, among others.
• Transition metal-catalyzed C,C- and C,N-cycloaminomethylation reactions of pyrrole and indole
  作者：Vnira R. Akhmetova、El’mira M. Bikbulatova、Nail S. Akhmadiev、Nailya F. Galimzyanova、Raikhana V. Kunakova、Askhat G. Ibragimov

  DOI：10.1007/s10593-018-2299-6

  日期：2018.5

  es or a mixture of alkyl(phenyl)amines and paraformaldehyde in the presence of [Ni(Py)4Cl2]·0.76H2O or NiCl2·6H2O catalysts proceeded at positions 2 and 5 of pyrrole ring. Cycloaminomethylation of indole was accomplished effectively at positions 1 and 3 in the presence of ZrOCl2·8H2O catalyst. When carbazole was treated with bis(methoxymethyl)alkylamine in the presence of ZrOCl2·8H2O catalyst, it was

  在[Ni（Py）4 Cl 2 ]·0.76H 2 O或NiCl 2 ·6H 2 O催化剂存在下，用双（甲氧基甲基）烷基胺或烷基（苯基）胺与低聚甲醛的混合物催化吡咯的环氨基甲基化吡咯环的2和5。在ZrOCl 2 ·8H 2 O催化剂存在下，吲哚的环氨基甲基化可在位置1和3处有效完成。当咔唑在ZrOCl 2 ·8H 2 O催化剂存在下用双（甲氧基甲基）烷基胺处理时，将其转化为N-氨基甲基化产物– N -[（9 H-咔唑-9-基）甲基] -N-（甲氧基甲基）烷基胺。