6-amino-N-[2-(4-hydroxyphenyl)ethyl]hexanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 6-amino-N-[2-(4-hydroxyphenyl)ethyl]hexanamide
• 化学式: C₁₄H₂₂N₂O₂
• mdl: MFCD13290672
• 分子量: 250.341
• InChiKey: JISHRFRBEWKWJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 叔丁氧羰酰基6-氨基己酸 在 N,N'-羰基二咪唑 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.0h， 生成 6-amino-N-[2-(4-hydroxyphenyl)ethyl]hexanamide
  参考文献：
  名称：

  Creating a 3D microenvironment for monocyte cultivation: ECM-mimicking hydrogels based on gelatine and hyaluronic acid derivatives

  摘要：

  一种基于明胶和透明质酸的共交联基质是适合用于THP-1细胞的三维培养的微环境，有助于促进它们向巨噬细胞的分化。

  DOI：

  10.1039/c7ra13739g

文献信息

• [EN] MEANS FOR USE IN PREPARATION OF HYDROGEL BASED ON HYDROXYPHENYL DERIVATIVE OF HYALURONAN, METHOD OF HYDROGEL PREPARATION AND USE THEREOF<br/>[FR] MOYEN DESTINÉ À ÊTRE UTILISÉ DANS UNE PRÉPARATION D'HYDROGEL À BASE DE DÉRIVÉ HYDROXYPHÉNYLE D'HYALURONANE, PROCÉDÉ DE PRÉPARATION D'HYDROGEL ET UTILISATION ASSOCIÉE
  申请人：CONTIPRO AS

  公开号：WO2020249143A1

  公开（公告）日：2020-12-17

  Means for use in a preparation of a hydrogel that comprises two separate solutions A and B, of which the solution A comprises enzyme horseradish peroxidase and the solution B comprises hydrogen peroxide, at least one solution A or B comprising calcium ions in form of a pharmaceutically acceptable salt and further the solution A and/or the solution B comprises hydroxyphenyl derivative of hyaluronan of a general formula (I), wherein n is in the range of 2 to 7500 and R is OH or a substituent NHR2CONHR1ArOH of a general formula (II), wherein Ar is phenylene and R1 ethylene or Ar is indolylene and R1 is ethylene or Ar is hydroxyphenylene and R1 is carboxyethylene, and R2 is alkylene of number of carbon atoms 3 to 7. The present invention further relates to the hydrogel based on hydroxyphenyl derivative of hyaluronan and the method of preparation and use thereof.

  用于制备羟基凝胶的方法，包括两种单独的溶液A和B，其中溶液A包括酶辣根过氧化物酶，溶液B包括过氧化氢，至少一种溶液A或B包括以药用可接受盐的形式的钙离子，而且溶液A和/或溶液B包括羟基苯基透明质酸衍生物，其一般式为(I)，其中n在2到7500的范围内，R为OH或一种一般式(II)的取代基NHR2CONHR1ArOH，其中Ar为苯基，R1为乙烯或Ar为吲哚基，R1为乙烯或Ar为羟基苯基，R1为羧基乙烯，R2为碳原子数为3到7的烷基。本发明还涉及基于羟基苯基透明质酸衍生物的羟基凝胶，以及其制备和使用方法。
• Derivates Based on Hyaluronic Acid, Capable of Forming Hydrogels, Method of Preparation Thereof, Hydrogels Based on Said Derivatives, Method of Preparation Thereof and Use
  申请人：Contipro Biotech s.r.o.

  公开号：US20150000561A1

  公开（公告）日：2015-01-01

  The invention relates to a new hyaluronan derivative according to the general formula (I), the method of preparation thereof, a hydrogel based on the new derivative, method of preparation of the hydrogel and the use of the hydrogel in tissue engineering, cosmetics, medicine or regenerative medicine, especially in the form of scaffolds for the treatment of articular cartilage or bone tissue defects.

  该发明涉及一种新的透明质酸衍生物，其通式为(I)，其制备方法，基于该新衍生物的水凝胶，水凝胶的制备方法以及水凝胶在组织工程、化妆品、医学或再生医学中的应用，尤其是作为治疗关节软骨或骨组织缺陷的支架的形式。
• Application of click chemistry for signal amplification in IHC and ISH assays
  申请人：Ventana Medical Systems, Inc.

  公开号：US11249085B2

  公开（公告）日：2022-02-15

  Applicants have developed an amplification system and methodology for IHC and ISH staining that utilizes “click chemistry” to covalently bind reporter molecules to tissue.

  申请人已开发出一种用于 IHC 和 ISH 染色的扩增系统和方法，它利用 "点击化学 "将报告分子与组织共价结合。
• DERIVATES BASED ON HYALURONIC ACID, CAPABLE OF FORMING HYDROGELS, METHOD OF PREPARATION THEREOF, HYDROGELS BASED ON SAID DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE
  申请人：Contipro Biotech s.r.o.

  公开号：EP2820051A1

  公开（公告）日：2015-01-07
• APPLICATION OF CLICK CHEMISTRY FOR SIGNAL AMPLIFICATION IN IHC AND ISH ASSAYS
  申请人：Ventana Medical Systems, Inc.

  公开号：US20210123922A1

  公开（公告）日：2021-04-29

  Applicants have developed an amplification system and methodology for IHC and ISH staining that utilizes “click chemistry” to covalently bind reporter molecules to tissue.