2-(benzo[d]thiazol-2-ylthio)-N-(4,5-diphenylthiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(benzo[d]thiazol-2-ylthio)-N-(4,5-diphenylthiazol-2-yl)acetamide
• 英文别名: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-(4,5-diphenyl-1,3-thiazol-2-yl)acetamide
• 化学式: C₂₄H₁₇N₃OS₃
• 分子量: 459.616
• InChiKey: VNNAMBCDQLPYMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-4,5-二苯基噻唑 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 2-(benzo[d]thiazol-2-ylthio)-N-(4,5-diphenylthiazol-2-yl)acetamide
  参考文献：
  名称：

  Synthesis and evaluation of novel diphenylthiazole derivatives as potential anti-inflammatory agents

  摘要：

  In the presented study, we synthesized a novel series of 18 diphenylthiazole derivatives and tested their anti-inflammatory properties. They showed significant anti-inflammatory properties in inflamed mice paws animal model. Docking-based analysis suggested that they act as COX enzyme inhibitors. The most potent compound 9e is significantly more active in reducing inflamed animal paws compared to diclofenac. Accordingly, we believe these compounds are good leads for further development into potent anti-inflammatory drugs.

  DOI：

  10.1007/s00044-015-1418-5

文献信息

• Synthesis and evaluation of novel diphenylthiazole derivatives as potential anti-inflammatory agents
  作者：Ahmed H. Abdelazeem、Maha Habash、Ibrahim A. Maghrabi、Mutasem O. Taha

  DOI：10.1007/s00044-015-1418-5

  日期：2015.10

  In the presented study, we synthesized a novel series of 18 diphenylthiazole derivatives and tested their anti-inflammatory properties. They showed significant anti-inflammatory properties in inflamed mice paws animal model. Docking-based analysis suggested that they act as COX enzyme inhibitors. The most potent compound 9e is significantly more active in reducing inflamed animal paws compared to diclofenac. Accordingly, we believe these compounds are good leads for further development into potent anti-inflammatory drugs.