乙氧基-(4-羟基苯基)次磷酸 | 77173-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 乙氧基-(4-羟基苯基)次磷酸
• 英文名称: 4-hydroxyphenyl phosphonic acid monoethyl ester
• 英文别名: Phosphonic acid, (4-hydroxyphenyl)-, monoethyl ester；ethoxy-(4-hydroxyphenyl)phosphinic acid
• CAS: 77173-37-6
• 化学式: C₈H₁₁O₄P
• 分子量: 202.147
• InChiKey: VYCILLWWQALGLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1'-(1,2-乙炔二基)二(4-甲基苯) 、 乙氧基-(4-羟基苯基)次磷酸 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 silver(I) acetate 、 silver carbonate 作用下， 以 叔丁醇 为溶剂， 反应 16.0h， 以76%的产率得到3,4-bis(4-methylphenyl)-1-ethoxy-6-hydroxy-benz[c-1,2]oxaphosphinine 1-oxide
  参考文献：
  名称：

  铑催化的氧化CH活化/环化反应合成磷酸异香豆素和磷2-吡喃酮

  摘要：

  已经开发了炔烃对次膦酸和膦酸单酯进行铑催化的环化反应。氧化环化反应可进行次膦酸衍生物的完全转化，从而可以经济高效地制备有用的磷化异香豆素，并实现了原子经济的制备。该反应耐受在次膦酸，膦酸单酯和炔烃上的广泛取代，包括卤化物，酮和羟基作为取代基。此外，我们发现烯基膦酸单酯通过与炔烃的氧化环化作用继续生成各种磷2-吡喃酮。机理研究表明，CH键金属化是限速步骤。

  DOI：

  10.1002/chem.201302652
• 作为产物：
  描述：

  (4-羟基-苯基)-磷酸二乙酯 在 水 、 sodium hydroxide 作用下， 生成 乙氧基-(4-羟基苯基)次磷酸
  参考文献：
  名称：

  炔烃和芳基膦酸单酯的铑催化环化反应合成磷酸异香豆素

  摘要：

  报道了使用炔烃和芳基膦酸单酯进行铑催化的环化反应，合成磷杂香豆素。许多芳基膦酸单酯以官能团耐受性高收率选择性环化。另外，以高区域选择性应用不对称炔烃。

  DOI：

  10.1021/ol401407v

文献信息

• Rhodium-Catalyzed Oxidative C-H Activation/Cyclization for the Synthesis of Phosphaisocoumarins and Phosphorous 2-Pyrones
  作者：Youngchul Park、Jungmin Seo、Sangjune Park、Eun Jeong Yoo、Phil Ho Lee

  DOI：10.1002/chem.201302652

  日期：2013.11.25

  Rhodium‐catalyzed cyclization of phosphinic acids and phosphonic monoesters with alkynes has been developed. The oxidative annulation proceeds with complete conversion of phosphinic acid derivatives and allowed the atom‐economic preparation of useful phosphaisocoumarins with high yield and selectivity. The reaction is tolerant of extensive substitution on the phosphinic acid, phosphonic monoester and alkyne, including

  已经开发了炔烃对次膦酸和膦酸单酯进行铑催化的环化反应。氧化环化反应可进行次膦酸衍生物的完全转化，从而可以经济高效地制备有用的磷化异香豆素，并实现了原子经济的制备。该反应耐受在次膦酸，膦酸单酯和炔烃上的广泛取代，包括卤化物，酮和羟基作为取代基。此外，我们发现烯基膦酸单酯通过与炔烃的氧化环化作用继续生成各种磷2-吡喃酮。机理研究表明，CH键金属化是限速步骤。
• NOVEL PHOSPHININE OXIDE DERIVATIVE AND PREPARATION METHOD THEREOF
  申请人：KNU-INDUSTRY COOPERATION FOUNDATION

  公开号：US20150344506A1

  公开（公告）日：2015-12-03

  Provided are a novel phosphinine oxide derivative and a preparation method thereof, and more specifically, the phosphinine oxide derivative includes an oxaphosphinine oxide derivative and an azaphosphinine oxide derivative. The phosphinine oxide derivative according to the present invention may have a pharmacological activity and a physiological activity, and may be used as a basic framework of a natural product and may be used for development of new drug and synthesis of various medical supplies. In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidant.

  提供了一种新型的膦氧衍生物及其制备方法，更具体地说，该膦氧衍生物包括氧代膦环氧衍生物和氮代膦环氧衍生物。根据本发明的膦氧衍生物可能具有药理活性和生理活性，并可用作天然产物的基本框架，可用于新药的开发和各种医疗用品的合成。此外，根据本发明的膦氧衍生物的制备方法，可以通过在铑（Rh）催化剂或钌（Ru）催化剂和氧化剂存在下使用磷酸衍生物和炔烃衍生物之间的分子内环化的简单合成过程来制备各种收率高的膦氧衍生物。
• AROMATIC POLYCARBONATE-STYRENE POLYMER RESIN COMPOSITION
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0767215A1

  公开（公告）日：1997-04-09

  An aromatic polycarbonate-styrene polymer resin composition comprising (A) an aromatic polycarbonate, (B) a specified rubber-modified styrene polymer, and (C) a compatibilizer comprising a copolymer of aromatic vinyl monomers wherein the distribution of the proportions of the comonomer components is so heterogeneous that the copolymer is composed of copolymer molecules having different solubility parameter (SP) values, that the difference in SP value between the copolymer molecule having the largest SP value and the copolymer molecule having the smallest SP value is 0.3-1.0 [(cal/cm3)0.5], and that the average SP value of the copolymer is 10.6-11.0 [(cal/cm3)0.5]. The composition has not only high impact and heat resistances but also high melt fluidity and is useful in the fields of household electric components and OA equipment components.

  一种芳香族聚碳酸酯-苯乙烯聚合物树脂组合物，包括(A)芳香族聚碳酸酯，(B)特定橡胶改性苯乙烯聚合物，和(C)由芳香族乙烯基单体共聚物组成的相容剂，其中共聚单体组分的比例分布非常不均匀，共聚物由具有不同溶解度参数（SP）值的共聚物分子组成，具有最大 SP 值的共聚物分子与具有最小 SP 值的共聚物分子之间的 SP 值差为 0.3-1.0 [(cal/cm3)0.5] ，共聚物的平均 SP 值为 10.6-11.0 [(cal/cm3)0.5] 。3-1.0 [(cal/cm3)0.5] ，共聚物的平均 SP 值为 10.6-11.0 [(cal/cm3)0.5] 。该组合物不仅具有较高的抗冲击性和耐热性，还具有较高的熔体流动性，可用于家用电气元件和 OA 设备元件领域。
• Aromatic polycarbonate-styrene polymer resin composition
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1125984A1

  公开（公告）日：2001-08-22

  Disclosed is an aromatic polycarbonate-styrene polymer resin composition comprising (A) an aromatic polycarbonate, (B) a specific rubber-modified styrene polymer and (C) a compatibility agent which is a copolymer containing an aromatic vinyl monomer and which has a non-uniform distribution with respect to the proportions of component monomers constituting the copolymer, so that the copolymer comprises copolymer molecules having different solubility parameter (SP) values, wherein the difference in SP value between the copolymer molecule having a maximum SP value and the copolymer molecule having a minimum SP value is from 0.3 to 1.0 [(cal/cm3)½], and wherein the copolymer has an average SP value of from 10.6 to 11.0 [(cal/cm3)½]. The aromatic polycarbonate-styrene polymer resin composition of the present invention has not only a high impact resistance and a high heat resistance but also a high melt flowability, so that it is useful in various industrial fields, especially, fields of parts for household electrical appliances, parts for office automation machines, and the like.

  本发明公开了一种芳香族聚碳酸酯-苯乙烯聚合物树脂组合物，该组合物包含(A)芳香族聚碳酸酯、(B)特定橡胶改性苯乙烯聚合物和(C)相容剂，相容剂是一种含有芳香族乙烯基单体的共聚物，该共聚物与构成共聚物的组分单体的比例分布不均匀、使该共聚物包括具有不同溶解度参数（SP）值的共聚物分子，其中具有最大 SP 值的共聚物分子与具有最小 SP 值的共聚物分子之间的 SP 值差为 0.3至1.0[(卡/立方厘米)½]，其中共聚物的平均SP值为10.6至11.0[(卡/立方厘米)½]。本发明的芳香族聚碳酸酯-苯乙烯聚合物树脂组合物不仅具有高抗冲击性和高耐热性，还具有高熔融流动性，因此可用于各种工业领域，特别是家用电器部件、办公自动化机器部件等领域。
• Flame retardant, high impact monovinylidene aromatic polymer composition
  申请人：——

  公开号：US20020035176A1

  公开（公告）日：2002-03-21

  Disclosed is a flame retardant, high impact monovinylidene aromatic polymer composition comprising suitable and sufficient amounts of a rubber modified monovinylidene aromatic polymer, a polyphenylene ether resin, a phosphorous compound, and an optional amount of phenol/aldehye resin as a partial substitute for the polyphenylene ether resin, which composition is rated V-2, V-1, V-0, or 5V in the Underwriter's Laboratories Standard 94 flammability test. More particularly the present invention provides a flame retardant, high impact monovinylidene aromatic polymer composition which can be easily processed comprising: (A) from 40 to 85 percent, based on the total weight of said composition, of comprising a rubber modified monovinylidene aromatic polymer (B) from 10 to 40 weight percent, based on the total weight of said composition, of a polyphenylene ether resin; and (C) from 5 to 20 weight percent, based on the total weight of said composition, of a phosphorous compound. Also disclosed the method of preparing the above-mentioned flame retardant compositions.

  本发明公开了一种阻燃、高抗冲单亚乙烯基芳香族聚合物组合物，该组合物包含适量和足量的橡胶改性单亚乙烯基芳香族聚合物、聚苯醚树脂、磷化合物和任选量的苯酚/甲醛树脂作为聚苯醚树脂的部分替代品，该组合物在保险商实验室标准 94 易燃性测试中的等级为 V-2、V-1、V-0 或 5V。更具体地说，本发明提供了一种阻燃、高抗冲单亚乙烯芳香族聚合物组合物，该组合物易于加工，其成分包括 (A) 以所述组合物总重量为基准，包含 40%至 85%的橡胶改性单亚乙烯基芳香族聚合物 (B) 基于所述组合物总重量，10%至 40%的聚苯醚树脂；以及 (C) 以所述组合物总重量为基准，5%至 20%的磷化合物。 还公开了上述阻燃剂组合物的制备方法。