2,6-dicyano-3,5-[N,N,N',N'-tetrakis(2-hydroxyethyl)amino]pyrazine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,6-dicyano-3,5-[N,N,N',N'-tetrakis(2-hydroxyethyl)amino]pyrazine
• 英文别名: 3,5-Bis[bis(2-hydroxyethyl)amino]pyrazine-2,6-dicarbonitrile；3,5-bis[bis(2-hydroxyethyl)amino]pyrazine-2,6-dicarbonitrile
• 化学式: C₁₄H₂₀N₆O₄
• 分子量: 336.351
• InChiKey: OAHHAESVRSTYFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  二乙醇胺 、 2,3,5,6-吡嗪四腈 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 2,6-dicyano-3,5-[N,N,N',N'-tetrakis(2-hydroxyethyl)amino]pyrazine
  参考文献：
  名称：

  WO2006/71759

  摘要：

  公开号：

文献信息

• Fluorescent pyrazine derivatives and methods of using the same in assessing renal function
  申请人：MALLINCKRODT, INC.

  公开号：EP1854790A1

  公开（公告）日：2007-11-14

  The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y' to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

  本发明涉及吡嗪衍生物，如式 I 和式 II 所代表的衍生物。式 I 和式 II 中的 X1 至 X4 可表征为取电子基团，而式 I 和式 II 中的 Y' 至 Y4 可表征为供电子基团。本发明的吡嗪衍生物可用于评估器官（如肾脏）功能。在一个特定的例子中，可将有效量的能被肾脏清除的吡嗪衍生物输入患者体内。吡嗪衍生物可以吸收和发射至少约 400nm 的光谱能量（如可见光和/或红外光）。体内的至少部分衍生物可暴露于光谱能量，反过来，光谱能量可从衍生物中发射出来。这种发射的光谱能量可被检测并用于确定患者的肾功能。
• Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function
  申请人：Rajagopalan Raghavan

  公开号：US20090010851A1

  公开（公告）日：2009-01-08

  The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X 1 to X 4 of Formulas I and II may be characterized as electron withdrawing groups, while Y 1 to Y 4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.
• FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION
  申请人：MediBeacon Inc.

  公开号：US20160280666A1

  公开（公告）日：2016-09-29

  The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X 1 to X 4 of Formulas I and II may be characterized as electron withdrawing groups, while Y 1 to Y 4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.
• US8778309B2
  申请人：——

  公开号：US8778309B2

  公开（公告）日：2014-07-15
• US9376399B2
  申请人：——

  公开号：US9376399B2

  公开（公告）日：2016-06-28