(1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
• 英文别名: (1S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
• 化学式: C₁₇H₁₇Cl₂N
• 分子量: 306.235
• InChiKey: VGKDLMBJGBXTGI-TYJDENFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 生成 (1S,4R)盐酸舍曲林 、 盐酸舍曲林
  参考文献：
  名称：

  WO2006/91732

  摘要：

  公开号：

文献信息

• Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using Amines with CF₃SO₂Cl
  作者：Jingjing Wei、Shuaishuai Liang、Lvqi Jiang、Wenbin Yi

  DOI：10.1021/acs.joc.0c01634

  日期：2020.10.2

  A practical and efficient method to synthesize thiocarbamyl fluorides and isothiocyanates from amines with trifluoromethanesulfonyl chloride was developed. In the presence of the reducing agent triphenylphosphine and sodium iodide, thiocarbamyl fluorides and isothiocyanates were synthesized from secondary/primary amine in moderate to excellent yields, respectively. A broad scope of substrates and good

  开发了一种实用有效的方法，由胺与三氟甲磺酰氯合成硫代氨基甲酰氟和异硫氰酸酯。在还原剂三苯基膦和碘化钠的存在下，由仲/伯胺分别以中等至优异的产率合成了硫代氨基甲酰氟和异硫氰酸酯。观察到广泛的底物范围和良好的官能团相容性。
• Compositions and methods for management of serotonin-mediated disorders
  申请人：——

  公开号：US20030083338A1

  公开（公告）日：2003-05-01

  The present invention provides methods and compositions for conjoint administration of a nefazodonoid and a fluoxetinoid for the treatment of depression and other neurological conditions.

  本发明提供了联合使用奈法唑酮和氟西汀酮治疗抑郁症和其他神经疾病的方法和组合物。
• Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
  申请人：Caron Judy

  公开号：US20080293726A1

  公开（公告）日：2008-11-27

  One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

  本发明的一个方面涉及药物组合物，其中包含两种或更多活性成分，当它们一起服用时，可用于治疗更年期、情绪障碍、焦虑障碍或认知障碍等疾病。药物组合物的第一成分是镇静药艾司唑仑。药物组合物的第二成分是反式4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺。本发明还涉及一种治疗更年期、围绝经期、情绪障碍、焦虑障碍和认知障碍的方法。
• Processes for preparing sertraline
  申请人：Ranjan Harish

  公开号：US20080114071A1

  公开（公告）日：2008-05-15

  Provided are processes for the preparation of sertraline and sertraline hydrochloride.

  提供了制备西酞普兰和西酞普兰盐酸盐的过程。
• Combinations of Eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, & Cognitive Disorders
  申请人：Sepracor Inc.

  公开号：EP2455075A1

  公开（公告）日：2012-05-23

  One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

  本发明的一个方面涉及含有两种或两种以上活性剂的药物组合物，这些活性剂一起服用时可用于治疗更年期、情绪障碍、焦虑症或认知障碍等疾病。药物组合物的第一种成分是镇静剂艾佐匹克隆。药物组合物的第二种成分是反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺或反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺。本发明还涉及一种治疗更年期、围绝经期、情绪障碍、焦虑障碍和认知障碍的方法。