N-[(3-nitrophenyl)-(2-hydroxynaphthalen-1-yl)methyl]acrylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(3-nitrophenyl)-(2-hydroxynaphthalen-1-yl)methyl]acrylamide
• 英文别名: N-[(2-hydroxynaphthalen-1-yl)(3-nitrophenyl)methyl]acrylamide；N-[(2-hydroxynaphthalen-1-yl)-(3-nitrophenyl)methyl]prop-2-enamide
• 化学式: C₂₀H₁₆N₂O₄
• 分子量: 348.358
• InChiKey: NQOJYHAELZNYLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间硝基苯甲醛 、 丙烯酰胺 、 2-萘酚 在 三聚氯氰 作用下， 反应 0.33h， 以95%的产率得到N-[(3-nitrophenyl)-(2-hydroxynaphthalen-1-yl)methyl]acrylamide
  参考文献：
  名称：

  在无溶剂条件下由2,4,6-三氯-1,3,5-三嗪催化三组分反应制备酰胺基烷基萘

  摘要：

  摘要描述了酰胺烷基萘的有效的一锅法合成。这涉及2-萘酚，芳族醛和酰胺或脲在催化剂量的2,4,6-三氯-1,3,5-三嗪（TCT，氰尿酰氯）存在下的三组分反应。免费条件。 图形概要

  DOI：

  10.1007/s00706-008-0059-5

文献信息

• Preparation of amidoalkyl naphthols by a three-component reaction catalyzed by 2,4,6-trichloro-1,3,5-triazine under solvent-free conditions
  作者：Peng Zhang、Zhan-Hui Zhang

  DOI：10.1007/s00706-008-0059-5

  日期：2009.2

  AbstractAn efficient one-pot synthesis of amidoalkyl naphthols is described. This involves the three-component reaction of 2-naphthol, aromatic aldehydes and amide or urea in the presence of a catalytic amount of 2,4,6-trichloro-1,3,5-triazine (TCT, cyanuric chloride) under solvent-free conditions. Graphical abstract

  摘要描述了酰胺烷基萘的有效的一锅法合成。这涉及2-萘酚，芳族醛和酰胺或脲在催化剂量的2,4,6-三氯-1,3,5-三嗪（TCT，氰尿酰氯）存在下的三组分反应。免费条件。 图形概要
• β-Cyclodextrin-butane sulfonic acid: an efficient and reusable catalyst for the multicomponent synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions
  作者：Kai Gong、Hualan Wang、Xiaoxue Ren、Ying Wang、Jinghua Chen

  DOI：10.1039/c5gc00384a

  日期：——

  A [small beta]-cyclodextrin-butane sulfonic acid is reported as an efficient catalyst for the one-pot synthesis of 1-amidoalkyl-2-naphthols by the multicomponent condensation of aromatic aldehydes, [small beta]-naphthol and amides under solvent-free conditions. The...

  据报道，小α-环糊精-丁磺酸是在溶剂-溶剂下通过芳香醛，小-萘酚和酰胺的多组分缩合一锅合成1-氨基烷基-2-萘的有效催化剂。免费条件。这...
• Nano Silica Sulfuric Acid an Efficient and Recoverable Heterogeneous Catalyst for the Preparation of Amidoalkyl Naphthols Under Solvent-Free Conditions
  作者：Keivan Ghodrati、Azita Farrokhi、Changiz Karami、Zohre Hamidi

  DOI：10.1080/15533174.2013.809746

  日期：2015.1.2

  An efficient and green method has been developed for the synthesis of amidoalkyl naphthol derivatives through a one-pot three-component condensation of 2-naphthol, aldehydes, and amide in the presence of nano silica sulfuric acid as heterogeneous catalyst under solvent-free conditions.

  在无溶剂条件下，以纳米二氧化硅硫酸为多相催化剂，在2-萘酚，醛和酰胺的一锅式三组分缩合反应中，开发了一种高效的绿色方法，用于合成氨基烷基萘酚衍生物。
• A Simple and Efficient Procedure for the Synthesis of Amidoalkyl Naphthols by <i>p</i>-TSA in Solution or under Solvent-Free Conditions
  作者：Mohammad Khodaei、Ahmad Khosropour、Hassan Moghanian

  DOI：10.1055/s-2006-939034

  日期：——

  An efficient and direct procedure for the synthesis of amidoalkyl naphthols has been described that employs a three-component condensation reaction in one pot using aromatic aldehydes, β-naphthol and ureas or amides in the presence of p-toluene sulfonic acid in 1,2-dichloroethane at room temperature or under solvent-free conditions at elevated temperature.

  已经描述了一种用于合成酰氨基烷基萘酚的有效且直接的方法，该方法在 1,2- 对甲苯磺酸存在下使用芳香醛、β-萘酚和脲或酰胺在一个锅中采用三组分缩合反应。二氯乙烷在室温下或在无溶剂条件下在升高的温度下。
• Cation‐Exchanged Resins: Efficient Heterogeneous Catalysts for Facile Synthesis of 1‐Amidoalkyl‐2‐naphthols from One‐Pot, Three‐Component Condensations of Amides/Ureas, Aldehydes, and 2‐Naphthol
  作者：Sachin B. Patil、Pankajkumar R. Singh、Mandar P. Surpur、Shriniwas D. Samant

  DOI：10.1080/00397910701263858

  日期：2007.5.1

  Abstract One‐pot, three‐component condensation of 2‐naphthol, amides/ureas, and aldehydes takes place smoothly in the presence of cation‐exchange resins to afford the corresponding 1‐amidoalkyl‐2‐naphthols in good yield. Indion‐130 is found to be the best catalyst for the reaction and is recyclable. The method is simple, solvent free, and involves a short reaction time.

  摘要 2-萘酚、酰胺/脲和醛的一锅三组分缩合反应在阳离子交换树脂的存在下顺利进行，以良好的收率得到相应的1-酰胺基烷基-2-萘酚。Indion-130 被发现是该反应的最佳催化剂，并且是可回收的。该方法简单，无溶剂，反应时间短。