5-nitro-1H-indazole-3-carbohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-nitro-1H-indazole-3-carbohydrazide
• 英文别名: 5-Nitro-1h-indazole-3-carbohydrazide
• 化学式: C₈H₇N₅O₃
• mdl: MFCD20924353
• 分子量: 221.175
• InChiKey: DAAPWUKVRMZEDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-吲哚甲醛 、 5-nitro-1H-indazole-3-carbohydrazide 在 溶剂黄146 作用下， 反应 6.0h， 以92%的产率得到N'-[(E)-(1H-indol-3-yl)methylidene]-5-nitro-1H-indazole-3-carbohydrazide
  参考文献：
  名称：

  Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives

  摘要：

  A series of ten novel hydrazide-hydrazones linked indole and indazole moieties were designed and synthesized. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7, and A549). Three of the synthesized compounds showed promising cytotoxicity specifically on some of the tested cell lines with IC50 values ranging between 1.93 and 25.6 mu M. Further, one compound was identified as a promising drug lead which showed promising cytotoxicity with IC50 value of 1.93 mu M towards MCF-7 breast cancer cell line as compared to the standard drug doxorubicin (IC50 value 0.98 mu M). While, all these new compounds showed no cytotoxicity on the normal human embryonic kidney cell line, HEK-293.

  DOI：

  10.1007/s00706-016-1750-6
• 作为产物：
  描述：

  5-硝基-1H-吲唑-3-羧酸甲酯 在 肼 作用下， 以 乙醇 为溶剂， 生成 5-nitro-1H-indazole-3-carbohydrazide
  参考文献：
  名称：

  Rudavath, Durgesh; Sreenivasulu, Reddymasu; Pinapati, Srinivasa Rao, Journal of the Indian Chemical Society, 2018, vol. 95, # 4, p. 433 - 438

  摘要：

  DOI：

文献信息

• Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives
  作者：Reddymasu Sreenivasulu、Pombala Sujitha、Surender Singh Jadav、Mohamed Jawed Ahsan、C. Ganesh Kumar、Rudraraju Ramesh Raju

  DOI：10.1007/s00706-016-1750-6

  日期：2017.2

  A series of ten novel hydrazide-hydrazones linked indole and indazole moieties were designed and synthesized. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7, and A549). Three of the synthesized compounds showed promising cytotoxicity specifically on some of the tested cell lines with IC50 values ranging between 1.93 and 25.6 mu M. Further, one compound was identified as a promising drug lead which showed promising cytotoxicity with IC50 value of 1.93 mu M towards MCF-7 breast cancer cell line as compared to the standard drug doxorubicin (IC50 value 0.98 mu M). While, all these new compounds showed no cytotoxicity on the normal human embryonic kidney cell line, HEK-293.
• Rudavath, Durgesh; Sreenivasulu, Reddymasu; Pinapati, Srinivasa Rao, Journal of the Indian Chemical Society, 2018, vol. 95, # 4, p. 433 - 438
  作者：Rudavath, Durgesh、Sreenivasulu, Reddymasu、Pinapati, Srinivasa Rao、Raju, Rudraraju Ramesh

  DOI：——

  日期：——