N-γ-linolenoyl ethanolamide | 150314-37-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-γ-linolenoyl ethanolamide
• 英文别名: linolenyl ethanolamide；N-(6Z,9Z,12Z-octadecatrienoyl)-ethanolamine；(6Z,9Z,12Z)-N-(2-hydroxyethyl)octadeca-6,9,12-trienamide
• CAS: 150314-37-7
• 化学式: C₂₀H₃₅NO₂
• 分子量: 321.503
• InChiKey: KRDUNUMTOBLEPM-QNEBEIHSSA-N

物化性质

• 沸点：
  499.3±45.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：25mg/mL； DMSO：25mg/mL；乙醇：50mg/mL；乙醇:PBS (pH 7.2)(1:2): 100 μg/ml
• 碰撞截面：
  193.49 Ų [M+H]+ [CCS Type: TIMS, Method: single field calibrated]

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  γ-亚麻酸 在 草酰氯 作用下， 生成 N-γ-linolenoyl ethanolamide
  参考文献：
  名称：

  大脑中与大麻素受体结合的两种新的不饱和脂肪酸乙醇酰胺。

  摘要：

  DOI：

  10.1021/jm00072a026

文献信息

• Ophthalmic, intra-articular or intravesical preparations containing N-acyl-ethanolamines
  申请人：Epitech Group S.r.l.

  公开号：EP2921171A1

  公开（公告）日：2015-09-23

  It is the object of the present invention a composition containing an N-acyl-ethanolamine in a solubilized form, particularly a solution for ophthalmic, intra-articular or intravesical use. Particularly, the present invention relates to a water-soluble composition comprising one or more N-acylethanolamines (NAE) in the form of an inclusion complex in methyl-beta-cyclodextrin (MβCD).

  本发明的目的是一种含有 N-酰基乙醇胺的溶解形式的组合物，特别是用于眼科、关节内或静脉内的溶液。 特别是，本发明涉及一种水溶性组合物，其中包含一种或多种以包合物形式存在于甲基-β-环糊精（MβCD）中的 N-酰乙醇胺（NAE）。
• INHIBITORS OF ANOREXIC LIPID HYDROLYSIS FOR THE TREATMENT OF EATING DISORDERS
  申请人：Hansen Harald S.

  公开号：US20090054526A1

  公开（公告）日：2009-02-26

  Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and/or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-ery-thro-2-(N-myristoylamino)-1-phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, cosmetic or a dietary supplements. The compounds, pharmaceuticals, cosmetic or dietary supplements and methods of the invention may further be used in modifying the feeding behaviour, suppression of hunger, enhancement of satiety, reduction of energy intake, reduction of fat tissue mass/lean mass ratio in a mammal (e.g. human).
• OPHTHALMIC, INTRA-ARTICULAR OR INTRAVESICAL PREPARATIONS CONTAINING N-ACYL-ETHANOLAMINES
  申请人：EPITECH GROUP S.R.I.

  公开号：US20150265551A1

  公开（公告）日：2015-09-24

  It is the object of the present invention a composition containing an N-acyl-ethanolamine in a solubilized form, particularly a solution for ophthalmic, intra-articular or intravesical use. Particularly, the present invention relates to a water-soluble composition comprising one or more N-acylethanolamines (NAE) in the form of an inclusion complex in methyl-beta-cyclodextrin (MβCD).
• US8420602B2
  申请人：——

  公开号：US8420602B2

  公开（公告）日：2013-04-16
• US9668986B2
  申请人：——

  公开号：US9668986B2

  公开（公告）日：2017-06-06