quetiapine besylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: quetiapine besylate
• 英文别名: Benzenesulfonic acid;2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
• 化学式: C₆H₆O₃S*C₂₁H₂₅N₃O₂S
• 分子量: 541.692
• InChiKey: UWPDKRZSWCGLIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.79
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苯磺酸 、 喹硫平 以 丙酮 为溶剂， 生成 quetiapine besylate
  参考文献：
  名称：

  QUETIAPINE SALTS AND THEIR POLYMORPHS

  摘要：

  本发明涉及quetiapine的新型和稳定盐形式、制备方法、制药组合物以及其治疗方法。更具体地，本发明提供了quetiapine的新型酸加成盐，其中酸对离子由苯磺酸、二苯乙酰-L-(+)-酒石酸和二-p-甲苯酰-L-(+)-酒石酸中的一种提供。本发明还提供了quetiapine盐的新型多形式，所述多形式选自quetiapine羟溴酸盐、quetiapine硫酸盐、quetiapine硝酸盐和quetiapine柠檬酸盐。

  公开号：

  US20100278878A1

文献信息

• US8101597B2
  申请人：——

  公开号：US8101597B2

  公开（公告）日：2012-01-24
• [EN] QUETIAPINE SALTS AND THEIR POLYMORPHS<br/>[FR] SELS DE QUÉTIAPINE ET LEURS POLYMORPHES
  申请人：ACTAVIS GROUP PTC EHF

  公开号：WO2009004480A2

  公开（公告）日：2009-01-08

  The present invention relates to novel and stable salt forms of quetiapine, processes for preparation, pharmaceutical compositions, and method of treating thereof. More particularly, the present invention provides novel acid addition salts of quetiapine wherein the acid counter ion is provided by an acid selected from the group consisting of benzene sulfonic acid, dibenzoyl-L-(+)-tartaric acid and di-p-toluoyl-L-(+)-tartaric acid. The present invention also provides novel polymorphic forms of quetiapine salts selected from the group consisting of quetiapine hydrobromide, quetiapine sulfate, quetiapine nitrate and quetiapine citrate.
• QUETIAPINE SALTS AND THEIR POLYMORPHS
  申请人：Dixit Girish

  公开号：US20100278878A1

  公开（公告）日：2010-11-04

  The present invention relates to novel and stable salt forms of quetiapine, processes for preparation, pharmaceutical compositions, and method of treating thereof. More particularly, the present invention provides novel acid addition salts of quetiapine wherein the acid counter ion is provided by an acid selected from the group consisting of benzene sulfonic acid, dibenzoyl-L-(+)-tartaric acid and di-p-toluoyl-L-(+)-tartaric acid. The present invention also provides novel polymorphic forms of quetiapine salts selected from the group consisting of quetiapine hydrobromide, quetiapine sulfate, quetiapine nitrate and quetiapine citrate.

  本发明涉及quetiapine的新型和稳定盐形式、制备方法、制药组合物以及其治疗方法。更具体地，本发明提供了quetiapine的新型酸加成盐，其中酸对离子由苯磺酸、二苯乙酰-L-(+)-酒石酸和二-p-甲苯酰-L-(+)-酒石酸中的一种提供。本发明还提供了quetiapine盐的新型多形式，所述多形式选自quetiapine羟溴酸盐、quetiapine硫酸盐、quetiapine硝酸盐和quetiapine柠檬酸盐。