4-(1,3-dioxan-2-yl)butanal

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 4-(1,3-dioxan-2-yl)butanal
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: JNMZFVMSUBJSLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1,3-dioxan-2-yl)butanal 在 盐酸 、 scandium tris(trifluoromethanesulfonate) 、 锌 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 49.0h， 生成 2-allyl-1-benzylpiperidine
  参考文献：
  名称：

  Synthesis of (±)-Lasubine II Using N -Methoxyamines

  摘要：

  AbstractThe synthesis of (±)‐lasubine II has been achieved through a three‐component allylation capitalizing on the unique properties of N‐methoxyamines. This reaction enabled the installation of all the carbon atoms of lasubine II in a single operation. The N‐methoxy group was efficiently used for the subsequent nitrone formation. A single‐step cyclization of isoxazolidines or N‐methoxyamines to form functionalized piperidine rings was also developed.

  DOI：

  10.1002/asia.201501143
• 作为产物：
  描述：

  戊二醛 、 1,3-丙二醇 在 碘 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到4-(1,3-dioxan-2-yl)butanal
  参考文献：
  名称：

  微波辅助对戊二醛及其对称衍生物如单缩醛和-硫缩醛的选择性保护

  摘要：

  合成了六种戊二醛的单保护缩醛和-硫缩醛及其对称的二甲基衍生物。事实证明，微波辅助加热是一种比传统加热更具选择性的单保护方法。所有反应都是有效的，并且仅形成痕量的双保护材料。

  DOI：

  10.1016/j.tet.2009.11.107

文献信息

• Simple Primary Anilines as Iminium Catalysts for the Epoxidation of α-Substituted Acroleins
  作者：Anniina Erkkilä、Petri M. Pihko、Melanie-Rose Clarke

  DOI：10.1002/adsc.200700048

  日期：2007.4.2

  Simple ortho-alkylated anilines have been shown to be excellent iminium catalysts for the epoxidation reaction of α-substituted acroleins. A range of different α-substituted acroleins give the epoxide products in good to excellent yields and good chemoselectivity.

  对于α-取代的丙烯醛的环氧化反应，简单的邻烷基化苯胺已被证明是极好的亚胺催化剂。一系列不同的α-取代的丙烯醛使环氧产物的收率高至优异，并具有良好的化学选择性。
• Compositions and Methods for Treating Neoplasia, Inflammatory Disease and Other Disorders
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20150150885A1

  公开（公告）日：2015-06-04

  The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
• US9320741B2
  申请人：——

  公开号：US9320741B2

  公开（公告）日：2016-04-26
• Synthesis of (±)-Lasubine II Using <i>N</i> -Methoxyamines
  作者：Takashi Yokoyama、Yutaro Fukami、Takaaki Sato、Noritaka Chida

  DOI：10.1002/asia.201501143

  日期：2016.2

  AbstractThe synthesis of (±)‐lasubine II has been achieved through a three‐component allylation capitalizing on the unique properties of N‐methoxyamines. This reaction enabled the installation of all the carbon atoms of lasubine II in a single operation. The N‐methoxy group was efficiently used for the subsequent nitrone formation. A single‐step cyclization of isoxazolidines or N‐methoxyamines to form functionalized piperidine rings was also developed.
• Microwave-assisted selective protection of glutaraldehyde and its symmetrical derivatives as monoacetals and -thioacetals
  作者：Heli Flink、Tiina Putkonen、Attila Sipos、Reija Jokela

  DOI：10.1016/j.tet.2009.11.107

  日期：2010.1

  Six monoprotected acetals and -thioacetals of glutaradehyde and its symmetrical dimethyl derivatives were synthesized. Microwave-assisted heating proved to be a substantially more selective method for monoprotection than conventional heating. All reactions were efficient and only traces of diprotected material were formed.

  合成了六种戊二醛的单保护缩醛和-硫缩醛及其对称的二甲基衍生物。事实证明，微波辅助加热是一种比传统加热更具选择性的单保护方法。所有反应都是有效的，并且仅形成痕量的双保护材料。