7,9-Dimethyl-4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡啶类
• 英文名称: 7,9-Dimethyl-4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidine
• 英文别名: 11,13-dimethyl-6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene
• 化学式: C₁₅H₁₆N₄O₂
• 分子量: 284.31
• InChiKey: HKPKBRAFJSEPFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Positive allosteric modulators of the muscarinic acetylcholine receptor M4
  申请人：Vanderbilt University

  公开号：US10239887B2

  公开（公告）日：2019-03-26

  Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

  本文公开的三环化合物包括嘧啶并[4′,5′:4,5]噻吩并[2,3-c]哒嗪-8-胺、吡啶并[3′,2′：4,5]噻吩并[3,2-d]嘧啶-4-胺、吡嗪并[2′,3′:4,5]噻吩并[3,2-d]嘧啶-4-胺、吡啶并[3′,2′：4,5]呋喃并[3,2-d]嘧啶-4-胺和嘧啶并[4′,5′:4,5]呋喃并[2,3-c]哒嗪-8-胺化合物，这些化合物可用作毒蕈碱乙酰胆碱受体M4（mAChR M4）的正异位调节剂。本文还公开了制造这些化合物的方法、包含这些化合物的药物组合物，以及使用这些化合物和组合物治疗与毒蕈碱乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。
• POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
  申请人：Vanderbilt University

  公开号：US20190161498A1

  公开（公告）日：2019-05-30

  Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.