benzil-amine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: benzil-amine
• 英文别名: benzilamine；benzilamin；1-(2-aminophenyl)-2-phenylethane-1,2-dione
• 化学式: C₁₄H₁₁NO₂
• 分子量: 225.247
• InChiKey: GFEPEQYRZIPEIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzil-amine 、 甲苯 在 叔丁基过氧化氢 、 copper(II) choride dihydrate 、 ammonium acetate 作用下， 以 水 为溶剂， 以62%的产率得到phenyl(2-phenylquinazolin-4-yl)methanone
  参考文献：
  名称：

  Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic CH aminations of methylarenes

  摘要：

  A novel copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes with 2-aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that C-H bond cleavage was the rate-determining step. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2015.07.008
• 作为试剂：
  描述：

  胡椒醛 、 硝基甲烷 在 benzil-amine 作用下， 以 溶剂黄146 、 异丙醇 为溶剂， 反应 1.0h， 以77%的产率得到5-((E)-2-nitroethenyl)-1,3-benzodioxole
  参考文献：
  名称：

  Bourguignon, Jean; Le Nard, Gilles; Queguiner, Guy, Canadian Journal of Chemistry, 1985, vol. 63, p. 2354 - 2361

  摘要：

  DOI：

文献信息

• alpha-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD
  申请人：NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY

  公开号：EP3932405A1

  公开（公告）日：2022-01-05

  The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate. The α-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.

  本发明提供了一种α-突触核蛋白聚集体结合剂，它对α-突触核蛋白聚集体具有高结合选择性。 α-突触核蛋白聚集体结合剂含有由式（I）代表的化合物、其药学上可接受的盐或其溶液： 在式 (I) 中，R1 和 R2 各自独立地选自氢、烷基、烯基、酰基和羟烷基组成的组；R3 是氢或卤素；环 A 是苯环或吡啶环；环 B 由下式 (i) 或 (ii) 表示： R4 和 R5 各自独立地选自氢、羟基、烷氧基、卤代烷氧基、卤代羟基烷氧基和氨基烷基组成的组。
• GAMMA-EMITTING RECEPTOR-BINDING QUINUCLIDINYL BENZILATES METHODS OF PREPARATION THEREOF AND IMAGING AND ASSAY METHODS UTILIZING SAME
  申请人：Research Corporation

  公开号：EP0052645B1

  公开（公告）日：1987-05-13
• EP0052645A4
  申请人：——

  公开号：EP0052645A4

  公开（公告）日：1983-03-29
• LUBRICANT COMPOSITION FOR CONTINUOUSLY VARIABLE TRANSMISSION
  申请人：Fujita Hiroshi

  公开号：US20120316092A1

  公开（公告）日：2012-12-13

  A lubricating oil composition for a continuously variable transmission contains at a specific content: (A) a mineral oil or PAO having a sulfur content of 0.03 mass % or less and a kinematic viscosity at 100 degrees C. from 1.5 mm 2 /s to 3 mm 2 /s; (B) a mineral oil or PAO having a sulfur content of 0.03 mass % or less and a kinematic viscosity at 100 degrees C. from 5.5 mm 2 /s to 8 mm 2 /s; (C) PAO having a kinematic viscosity at 100 degrees C. from 30 mm 2 /s to 400 mm 2 /s; and (D) a polymethacrylate having a mass average molecular weight of 10000 to 40000, in which the total content of the components (C) and (D) is 19 mass % or more and the lubricating oil composition has a kinematic viscosity at 100 degrees C. from 5.5 mm 2 /s to 6.5 mm 2 /s and a kinematic viscosity at −20 degrees C. of 680 mm 2 /s or less.
• ARYLAMINE COMPOUND
  申请人：GOTO Daisuke

  公开号：US20130225858A1

  公开（公告）日：2013-08-29

  An arylamine compound including: a partial structure shown in formula (1-1) or (1-2), wherein either X or Y is one of leaving substituents and the other is a hydrogen atom; either (X 1 , X 2 ) or (Y 1 , Y 2 ) is one of the leaving substituents respectively and the other is the hydrogen atom respectively; each of Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , and Q 6 is selected from the hydrogen atom, a halogen atom, organic substituents other than the leaving substituents, and an atomic bonding to link with an adjacent arylamine group respectively; and adjacent two substituents selected from Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , and Q 6 may be linked together to form the ring which may be a part of an arylamine group.