达库溴铵 | 27115-86-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 达库溴铵
• 英文名称: Dacuronium Bromide
• 英文别名: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-hydroxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide
• CAS: 27115-86-2
• 化学式: C33H58Br2N2O3
• 分子量: 690.6
• InChiKey: SUKULMJPMHYWKC-GMMLHHOXSA-L

物化性质

• 熔点：
  210-215°C (dec.)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.45
• 重原子数：
  40
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• 6-deoxy-6-thioether-amino acid cyclodextrin derivative and preparation method thereof
  申请人：Qi Youmao

  公开号：US10017584B2

  公开（公告）日：2018-07-10

  6-deoxy-6-thioether-amino acid cyclodextrin derivative is obtained by condensing an amino acid derivative with halogenated cyclodextrin in presence of alkali. The 6-deoxy-6-thioether-amino acid cyclodextrin derivative includes 6-deoxysulfinyl-6-thioether-amino acid cyclodextrin derivative and 6-deoxysulfonyl-6-thioether-amino acid cyclodextrin derivative. Compounds provided are for reversing neuromuscular relaxation in patients and animals induced by muscular relaxants. The compounds are able to rapidly reverse and antagonize muscular relaxation induced by muscular relaxants and can be administrated in preparing a drug having an antagonist effect on muscular relaxation. The compounds have a general formula (I).

  6-脱氧-6-硫醚-氨基酸环糊精衍生物是由氨基酸衍生物与卤化环糊精在碱存在下缩合而成。6-脱氧-6-硫醚-氨基酸环糊精衍生物包括 6-脱氧亚磺酰基-6-硫醚-氨基酸环糊精衍生物和 6-脱氧磺酰基-6-硫醚-氨基酸环糊精衍生物。所提供的化合物用于逆转肌肉松弛剂诱导的患者和动物的神经肌肉松弛。这些化合物能够快速逆转和拮抗由肌肉松弛剂诱导的肌肉松弛，可以在制备对肌肉松弛有拮抗作用的药物时使用。这些化合物的通式为 (I)。
• Pharmaceutical preparations, use of these preparations and process for increasing the biovailability of pharmaceutical substances to be administered perorally
  申请人：——

  公开号：US20040223983A1

  公开（公告）日：2004-11-11

  The invention relates to pharmaceutical preparations that contain at least one emulsifier, at least one auxiliary emulsifier and/or solvent as well as at least one lipid, characterized in that the mass ratio of emulsifier to auxiliary emulsifier and/or solvent (Smix) is 1:1 to 9:1 and the total lipid proportion is >0% (m/m), whereby this preparation at least partially inhibits at least one intestinal enzyme and/or at least one intestinal efflux system. These preparations can be used to increase the bioavailability of pharmaceutical substances that are lipophilic and/or substrates of intestinal metabolizing enzymes and/or intestinal efflux systems, especially steroids.

  本发明涉及含有至少一种乳化剂、至少一种辅助乳化剂和/或溶剂以及至少一种脂质的药物制剂，其特征在于乳化剂与辅助乳化剂和/或溶剂（Smix）的质量比为1:1至9:1，总脂质比例大于0%（m/m），从而该制剂至少部分抑制至少一种肠道酶和/或至少一种肠道外流系统。这些制剂可用于提高亲脂性和/或肠道代谢酶和/或肠道外排系统底物的药物物质（尤其是类固醇）的生物利用度。
• 6-DEOXY-6-THIOETHER-AMINO ACID CYCLODEXTRIN DERIVATIVES AND PREPARATION METHOD THEREOF
  申请人：Hangzhou Adamerck Pharmlabs Inc.

  公开号：EP2644624B1

  公开（公告）日：2017-02-22
• Methods and devices for the treatment of ocular conditions
  申请人：deJuan Eugene

  公开号：US20060110428A1

  公开（公告）日：2006-05-25

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.