二1－二甲胺基萘－5－磺酰-L-赖氨酸 | 1263-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 二1－二甲胺基萘－5－磺酰-L-赖氨酸
• 英文名称: didansyllysine
• 英文别名: N,N'-Didansyl-L-lysine；Didansyl-L-lysine；(2S)-2,6-bis[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanoic acid
• CAS: 1263-03-2
• 化学式: C₃₀H₃₆N₄O₆S₂
• 分子量: 612.771
• InChiKey: OLAZYTPTPLUAPK-VWLOTQADSA-N

物化性质

• 沸点：
  809.5±75.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  10

安全信息

• WGK Germany：
  3
• 海关编码：
  2935009090

反应信息

• 作为产物：
  描述：

  丹酰氯 、 N,N'-双芴甲氧羰基-L-赖氨酸 在 N,N-二异丙基乙胺 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 二1－二甲胺基萘－5－磺酰-L-赖氨酸
  参考文献：
  名称：

  Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells

  摘要：

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.106

文献信息

• Apparatus and method for performing microfluidic manipultions for chemical analysis and synthesis
  申请人：LOCKHEED MARTIN ENERGY SYSTEMS, INC.

  公开号：EP1162455A1

  公开（公告）日：2001-12-12

  A microchip laboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochomatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).

  微芯片实验室系统（10）和方法可为各种应用提供流体操作，包括用于微芯片化学分离的样品注入。微芯片采用标准光刻程序和化学湿法蚀刻工艺制作，基片和盖板采用直接键合方式连接。毛细管电泳和电层析在基片上形成的通道（26、28、30、32、34、36、38）中进行。通过电动力泵将分析物通过交叉点（40），然后切换电位，将分析物塞入分离通道（34），从而将分析物装入通道的四向交叉点。
• Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
  申请人：UT-Battelle, LLC

  公开号：EP1382962A1

  公开（公告）日：2004-01-21

  A microchip laboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochomatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).

  微芯片实验室系统（10）和方法可为各种应用提供流体操作，包括用于微芯片化学分离的样品注入。微芯片采用标准光刻程序和化学湿法蚀刻工艺制作，基片和盖板采用直接键合方式连接。毛细管电泳和电层析在基片上形成的通道（26、28、30、32、34、36、38）中进行。通过电动力泵将分析物通过交叉点（40）装入通道的四向交叉点，然后切换电位，迫使分析物塞入分离通道（34）。
• Apparatus and method for performing microfluidic manipulations for chemical analysis and sysnthesis
  申请人：——

  公开号：US20030150733A1

  公开（公告）日：2003-08-14

  A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

  微芯片实验室系统和方法可为各种应用提供流体操作，包括用于微芯片化学分离的样品注入。微芯片采用标准的光刻程序和化学湿法蚀刻工艺制作而成，基片和盖板采用直接键合方式连接。毛细管电泳和电色谱在基片上形成的通道中进行。通过电动力泵将分析物通过交叉点，然后切换电位，将分析物塞入分离通道，从而将分析物装入通道的四向交叉点。
• Tamper-resistant authentication mark for use in product or product packaging authentication
  申请人：——

  公开号：US20040023397A1

  公开（公告）日：2004-02-05

  A method of authenticating products or packaging by analyzing key ingredients on products or on product packaging is disclosed. Light-sensitive compounds can be used to identify the product or product packaging. The product or product package may include visible or invisible ink containing a particular light-sensitive compound. One or more light-sensitive compounds and ink, if used, may be printed in one or more locations on the product or product packaging to produce an authentication mark to inhibit inadvertent or intentional removal of the mark, thereby rendering the mark tamper-resistant. The mark is sealed to isolate the mark from the environment. A device may be used to irradiate the mark and read light absorption or emission. A controller determines the authenticity of the mark by comparing the emitted or absorbed properties to a standard.

  本发明公开了一种通过分析产品或产品包装上的关键成分来鉴定产品或包装的方法。光敏化合物可用于识别产品或产品包装。产品或产品包装可包括含有特定光敏化合物的可见或不可见油墨。可以在产品或产品包装上的一个或多个位置印上一种或多种光敏化合物和墨水（如果使用），以产生验证标记，防止无意或有意去除标记，从而使标记具有防篡改功能。标记被密封起来，使标记与环境隔离。可使用一个装置照射标记并读取光吸收或发射。控制器通过将发射或吸收特性与标准进行比较来确定标记的真伪。
• Perturbed membrane-binding compounds
  申请人：——

  公开号：US20040082499A1

  公开（公告）日：2004-04-29

  The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to cell having membranes of normal organization. These compounds are termed perturbed-membrane-binding compounds (PMBC). The PMBC group of compounds includes new compounds and also known compounds.

  本发明提供了一些化合物的用途，这些化合物可选择性地与正常膜组织发生紊乱和改变的细胞结合，同时与具有正常组织的细胞膜的结合程度较低。这些化合物被称为扰动膜结合化合物（PMBC）。PMBC 类化合物包括新化合物和已知化合物。