N.N.N'.N'-Tetraethyl-formamidinium-methylsulfat

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: N.N.N'.N'-Tetraethyl-formamidinium-methylsulfat
• 英文别名: N,N,N',N'-tetraethylformamidinium methylsulfate；N,N,N',N'-Tetraethylformamidinium methylsulfate；diethylaminomethylidene(diethyl)azanium;methyl sulfate
• 化学式: CH₃O₄S*C₉H₂₁N₂
• 分子量: 268.378
• InChiKey: IJCMMXJMUHUOOA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  81.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N.N.N'.N'-Tetraethyl-formamidinium-methylsulfat 在 ammonium hexafluorophosphate 作用下， 以 水 为溶剂， 生成 tetraethylformamidinium hexafluorophosphate
  参考文献：
  名称：

  [EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTAN0IC ACID DERIVATIVES
  [FR] NOUVEAUX PROCÉDÉS

  摘要：

  公开号：

  WO2009090251A3
• 作为产物：
  描述：

  N,N-二乙基甲酰胺 、 二乙胺 、 硫酸二甲酯 生成 N.N.N'.N'-Tetraethyl-formamidinium-methylsulfat
  参考文献：
  名称：

  Bredereck,H. et al., Chemische Berichte, 1968, vol. 101, p. 1885 - 1888

  摘要：

  DOI：

文献信息

• NEW PROCESSES
  申请人：Hook David

  公开号：US20110046397A1

  公开（公告）日：2011-02-24

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种生产NEP抑制剂或其前药的新工艺，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。详细来说，根据本发明，新工艺最终与合成制备上述NEP抑制剂的中间体相关，即按照公式（1）或其盐制备的化合物，其中R1和R2独立地是氢或氮保护基，R3是羧基或酯基，优选是羧基或烷基酯。
• Processes
  申请人：Hook David

  公开号：US08580974B2

  公开（公告）日：2013-11-12

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种生产NEP抑制剂或其前药的新工艺，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。具体而言，根据本发明，新工艺最终涉及合成中间体以制备上述NEP抑制剂，即按式（1）或其盐制备的化合物，其中R1和R2独立地是氢或氮保护基，R3是羧基或酯基，优选为羧基或烷基酯。
• Processes for producing NEP inhibitors or prodrugs thereof
  申请人：Hook David

  公开号：US09061973B2

  公开（公告）日：2015-06-23

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种生产NEP抑制剂或其前药的新工艺，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。具体而言，根据本发明，新工艺最终与合成中间体有关，以制备上述NEP抑制剂，即按式（1）或其盐的化合物，其中R1和R2独立地为氢或氮保护基，R3为羧基或酯基，优选为羧基或烷基酯。
• Intermediates for producing NEP inhibitors or prodrugs thereof
  申请人：Hook David

  公开号：US09403766B2

  公开（公告）日：2016-08-02

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种新的生产NEP抑制剂或其前药的方法，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。具体而言，根据本发明，新的方法最终与合成中间体有关，以制备上述NEP抑制剂，即按照式（1）或其盐的化合物，其中R1和R2独立地是氢或氮保护基，R3是羧基或酯基，优选为羧基或烷基酯。
• PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTANOIC ACID DERIVATIVES
  申请人：Novartis AG

  公开号：EP2245009A2

  公开（公告）日：2010-11-03