Z-L-His(Trt)-OH

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Z-L-His(Trt)-OH
• 英文别名: (2S)-2-(phenylmethoxycarbonylamino)-3-(3-tritylimidazol-4-yl)propanoic acid
• 化学式: C₃₃H₂₉N₃O₄
• 分子量: 531.611
• InChiKey: PHCKBXMWBBELCA-PMERELPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Z-L-His(Trt)-OH 在 N-甲基吗啉 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 13.5h， 生成 Z-L-His-L-(αMe)Phe-OMe
  参考文献：
  名称：

  Catalytic enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxybenzaldehyde using cyclo-His-(α-Me)Phe as catalyst

  摘要：

  Two cyclo-dipeptides based on His and the unnatural (alpha Me)Phe have been examined as catalysts in the enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis, catalytic activity and NMR study towards the mechanism of this reaction are presented. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00178-x
• 作为产物：
  描述：

  L-组氨酸 在 sodium hydroxide 、 碳酸氢钠 、 三乙胺 、 二氯二甲基硅烷 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 生成 Z-L-His(Trt)-OH
  参考文献：
  名称：

  Catalytic enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxybenzaldehyde using cyclo-His-(α-Me)Phe as catalyst

  摘要：

  Two cyclo-dipeptides based on His and the unnatural (alpha Me)Phe have been examined as catalysts in the enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis, catalytic activity and NMR study towards the mechanism of this reaction are presented. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00178-x

文献信息

• NOVEL THIAZOLIDINE DERIVATIVES
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1103560A1

  公开（公告）日：2001-05-30

  An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented by the following general formula [I] and salts thereof, wherein R1 is alkyl, hydroxy, alkoxy, alkoxyalkyl, phenyl, phenylalkyl, phenylalkoxy, phenoxy, phenoxyalkyl, amino, alkylamino or a nonaromatic heterocycle; R2 is H or alkyl; R3 is H, alkyl or phenyl; R4 is H or alkyl; R5 is alkyl, halogenoalkyl, hydroxy, alkoxy, phenyl, phenylalkoxy, phenoxy, carboxyl, alkoxycarbonyl, phenylalkoxycarbonyl or an aromatic heterocycle; A1 is alkylene; and A2 is alkylene.

  本发明的目的是提供可用作药物的新型噻唑烷衍生物。根据本发明的噻唑烷衍生物是由以下通式[I]代表的化合物及其盐类、 其中 R1 是烷基、羟基、烷氧基、烷氧基烷基、苯基、苯基烷基、苯基烷氧基、苯氧基、苯氧基烷基、氨基、烷基氨基或非芳香杂环；R2 是 H 或烷基；R3 是 H、烷基或苯基；R4 是 H 或烷基；R5 是烷基、卤代烷基、羟基、烷氧基、苯基、苯基烷氧基、苯氧基、羧基、烷氧基羰基、苯基烷氧基羰基或芳香杂环；A1 是亚烷基；A2 是亚烷基。
• US6410576B1
  申请人：——

  公开号：US6410576B1

  公开（公告）日：2002-06-25
• Catalytic enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxybenzaldehyde using cyclo-His-(α-Me)Phe as catalyst
  作者：Ron Hulst、Quirinus B. Broxterman、Johan Kamphuis、Fernando Formaggio、Marco Crisma、Claudio Toniolo、Richard M. Kellogg

  DOI：10.1016/s0957-4166(97)00178-x

  日期：1997.6

  Two cyclo-dipeptides based on His and the unnatural (alpha Me)Phe have been examined as catalysts in the enantioselective addition of hydrogen cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis, catalytic activity and NMR study towards the mechanism of this reaction are presented. (C) 1997 Elsevier Science Ltd.