ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)-methyl]-1-piperidinecarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)-methyl]-1-piperidinecarboxylate
• 英文别名: ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)methyl]-1-piperidinecarboxylate；ethyl 4-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)piperidine-1-carboxylate
• 化学式: C₁₅H₂₀N₄O₂
• 分子量: 288.349
• InChiKey: GHBNSPBYQRCCIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  71.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)-methyl]-1-piperidinecarboxylate 、 2-溴苯乙酮 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 1.0h， 以50.5%的产率得到ethyl 4-[[1-(2-oxo-2-phenylethyl)-1H-imidazo[4,5-b]pyridin-2-yl]-methyl]-1-piperidinecarboxylate
  参考文献：
  名称：

  RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS

  摘要：

  公开号：

  EP1196409B1
• 作为产物：
  描述：

  2,3-二氨基吡啶 、 ethyl 4-(2-ethoxy-2-iminoethyl)-1-piperidinecarboxylate monohydrochloride 在 potassium carbonate 、 silica gel 、 Dichloromethane methanol ammonium hydroxide 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以yielding 7.6 g of ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)methyl]-1-piperidinecarboxylate (52%) (interm. 9)的产率得到ethyl 4-[(1H-imidazo[4,5-b]pyridin-2-yl)-methyl]-1-piperidinecarboxylate
  参考文献：
  名称：

  Respiratory Syncytial Virus Replication Inhibitors

  摘要：

  本发明涉及式(I)的化合物，它们是前药、加成盐或立体化学异构体形式，可用作呼吸道合胞病毒复制抑制剂，其制备方法、包含它们的组合物以及在治疗呼吸道合胞病毒感染方面使用它们的方法。

  公开号：

  US20070135404A1

文献信息

• Respiratory syncytial virus replication inhibitors
  申请人：Janssen Pharmaceutica, N.V.

  公开号：US07179811B2

  公开（公告）日：2007-02-20

  This invention concerns compounds of formula (I) prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and methods of their use in treating respiratory syncytial viral infections.

  本发明涉及公式（I）的化合物，它们是前药、加成盐或立体化学异构体形式，用于作为呼吸道合胞病毒复制抑制剂等用途；它们的制备、含有它们的组合物以及在治疗呼吸道合胞病毒感染方面使用它们的方法。
• US6747028B1
  申请人：——

  公开号：US6747028B1

  公开（公告）日：2004-06-08
• US7179811B2
  申请人：——

  公开号：US7179811B2

  公开（公告）日：2007-02-20
• US7528149B2
  申请人：——

  公开号：US7528149B2

  公开（公告）日：2009-05-05
• [EN] RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS<br/>[FR] INHIBITEURS DE REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2001000612A2

  公开（公告）日：2001-01-04

  This invention concerns the compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a?1=a2-a3=a4¿- is a radical of formula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), wherein Alk is C¿1-6?alkanediyl; Y?1¿ is a bivalent radical of formula-NR2- or -CH(NR?2R4)-; X1 is NR4¿, S, S(=O), S(=O)¿2?, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR?5aR5b), CH¿2-NR?4 or NR4-CH¿2; X2 is a direct bond, CH¿2?, C(=O), NR?4, C¿1-4alkyl-NR?4, NR4-C¿1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C¿1-6?alkyloxy, then R?3¿ can not replace a hydrogen atom in the α position relative to a nitrogen atom; G is substituted C¿1-10?alkanediyl wherein the substituent is attached via an oxygen atom; R?1¿ is an optionally substituted monocyclic heterocycle or aryl; R2 is hydrogen, formyl, C¿1-6?alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R?6)¿2 and optionally with another substituent; R3 is hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy; R?4¿ is hydrogen, C¿1-6?alkyl or arylC1-6alkyl; R?5a, R5b, R5c and R5d¿ are hydrogen or C¿1-6?alkyl; or R?5a and R5b, or R5c and R5d¿ taken together form a bivalent radical of formula -(CH¿2?)s- wherein s is 4 or 5; R?6¿ is hydrogen, C¿1-4?alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.