Total Synthesis of Hoiamide A Using an Evans–Tishchenko Reaction as a Key Step
作者:Yian Guo、Jingjing Zhou、Bowen Gao、Meng Zhao、Jia-Lei Yan、Zhengshuang Xu、Sun Choi、Tao Ye
DOI:10.1021/acs.orglett.9b01735
日期:2019.7.19
The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans–Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine.
A new peptide bond surrogate: 2-isoxazoline in pseudodipeptide chemistry
作者:Byeang Hyean Kim、Yong Jun Chung、Gyochang Keum、Jaheon Kim、Kimoon Kim
DOI:10.1016/s0040-4039(00)61782-3
日期:1992.11
The 2-isoxazoline ring has been incorporated as a new peptide bond surrogate into pseudodipeptide. An easy and versatile general method for the preparation of pseudodipeptides is described.
Rassu, Gloria; Zanardi, Franca; Cornia, Mara, Journal of the Chemical Society. Perkin transactions I, 1994, # 17, p. 2431 - 2438
作者:Rassu, Gloria、Zanardi, Franca、Cornia, Mara、Casiraghi, Giovanni