1-propyl-6,7-dihydroxyisochroman

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-propyl-6,7-dihydroxyisochroman
• 英文别名: 1-Propylisochroman-6,7-diol；1-propyl-3,4-dihydro-1H-isochromene-6,7-diol
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: NANRBCDRUZZOMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  羟基酪醇 、 正丁醛 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以64%的产率得到1-propyl-6,7-dihydroxyisochroman
  参考文献：
  名称：

  Isochromans from 2-(3′,4′-dihydroxy)phenylethanol

  摘要：

  A facile method to obtain an isochromanic structure was achieved by the oxa-Pictet-Spengler reaction using 2-(3',4'-dihydroxy)phenylethanol as starting material. The reaction was performed in very mild conditions on a series of carbonylic compounds. Yields were always satisfactory. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01307-7

文献信息

• Isochromans from 2-(3′,4′-dihydroxy)phenylethanol
  作者：Marcella Guiso、Carolina Marra、Claudia Cavarischia

  DOI：10.1016/s0040-4039(01)01307-7

  日期：2001.9

  A facile method to obtain an isochromanic structure was achieved by the oxa-Pictet-Spengler reaction using 2-(3',4'-dihydroxy)phenylethanol as starting material. The reaction was performed in very mild conditions on a series of carbonylic compounds. Yields were always satisfactory. (C) 2001 Elsevier Science Ltd. All rights reserved.