cholesteryl chloroformate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesteryl chloroformate
• 英文别名: [(8S,9S,10R,13R,14S)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] carbonochloridate
• 化学式: C₂₈H₄₅ClO₂
• 分子量: 449.117
• InChiKey: QNEPTKZEXBPDLF-BXGVZDCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cholesteryl chloroformate 在 吡啶 、 三乙胺 、 potassium hydroxide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.5h， 生成 2-[[(8S,9S,10R,13R,14S)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbonylamino]ethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate
  参考文献：
  名称：

  [EN] COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
  [FR] HYDROGELS COMPOSITES POUR L'ADMINISTRATION DE MATIÈRES BIOLOGIQUEMENT ACTIVES

  摘要：

  一种复合水凝胶包括一种亲疏性三嵌段共聚物（ABA）和一个由非共价相互作用结合的载荷胶束。所述载荷胶束包括一种生物活性物质和一种亲疏性二嵌段共聚物（CD）。所述A块包括一种类固醇重复单元（重复单元1），其具有主干碳酸酯和侧链带有类固醇官能团。每个A块的聚合度约为0.5到4.0。B块包括第一种聚（烷氧基）主干。C块包括第二种聚（烷氧基）主干。D块包括一种类固醇重复单元（重复单元2），其具有主干碳酸酯基和侧链包括类固醇官能团。该复合水凝胶能够控制释放生物活性物质。

  公开号：

  WO2014042921A1

文献信息

• BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
  申请人：Cheng Wei

  公开号：US20140080215A1

  公开（公告）日：2014-03-20

  A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n′+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L′ is a divalent radical comprising 3 to 30 carbons, and q/(n′+q)×100% equals about 9% to about 47%.
• US8703197B2
  申请人：——

  公开号：US8703197B2

  公开（公告）日：2014-04-22
• US8834861B2
  申请人：——

  公开号：US8834861B2

  公开（公告）日：2014-09-16
• [EN] BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS<br/>[FR] POLYAMINES RAMIFIÉES POUR L'ADMINISTRATION DE MATIÈRES BIOLOGIQUEMENT
  申请人：IBM

  公开号：WO2014042920A1

  公开（公告）日：2014-03-20

  A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n' greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): — CH2-CH2-N— Is. ^O-L'-O H (2), wherein (n'+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L' is a divalent radical comprising 3 to 30 carbons, and q/(n' + q) x 100% equals about 9% to about 47%.
• [EN] COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS<br/>[FR] HYDROGELS COMPOSITES POUR L'ADMINISTRATION DE MATIÈRES BIOLOGIQUEMENT ACTIVES
  申请人：IBM

  公开号：WO2014042921A1

  公开（公告）日：2014-03-20

  A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.

  一种复合水凝胶包括一种亲疏性三嵌段共聚物（ABA）和一个由非共价相互作用结合的载荷胶束。所述载荷胶束包括一种生物活性物质和一种亲疏性二嵌段共聚物（CD）。所述A块包括一种类固醇重复单元（重复单元1），其具有主干碳酸酯和侧链带有类固醇官能团。每个A块的聚合度约为0.5到4.0。B块包括第一种聚（烷氧基）主干。C块包括第二种聚（烷氧基）主干。D块包括一种类固醇重复单元（重复单元2），其具有主干碳酸酯基和侧链包括类固醇官能团。该复合水凝胶能够控制释放生物活性物质。