2-hydroxy-N.N,N-tributylethanammonium bromide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxy-N.N,N-tributylethanammonium bromide
• 英文别名: 2-hydroxy-N,N,N-tributylethanaminium bromide；tri-n-butyl(2-hydroxyethyl)ammonium bromide；2-hydroxyl-ethyl-tributylammonium bromide；[hetba]Br；2-Hydroxyethyltributylammonium bromide；tributyl(2-hydroxyethyl)azanium;bromide
• 化学式: Br*C₁₄H₃₂NO
• 分子量: 310.318
• InChiKey: DOZCQOXWNBGYHT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N.N,N-tributylethanammonium bromide 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 0.03h， 以93%的产率得到
  参考文献：
  名称：

  Reductive Amination of Aldehydes and Ketones with 2-(Tributylamino)-ethoxyborohydride

  摘要：

  A new ionic liquid is presented as a medium and reducing agent for the reductive amination of aldehydes and ketones.

  DOI：

  10.1007/s00706-007-0750-y
• 作为产物：
  描述：

  三正丁胺 、 2-溴乙醇 以 neat (no solvent) 为溶剂， 反应 24.0h， 以49%的产率得到2-hydroxy-N.N,N-tributylethanammonium bromide
  参考文献：
  名称：

  用于将二氧化碳加成环氧化物的双功能单组分催化剂

  摘要：

  合成了几种双功能铵盐，并将其用作单组分催化剂，用于将CO 2和环氧化物转化为环状碳酸酯。与它们的单官能类似物相比，这些催化剂显示出优异的活性。周转次数最多为693，周转频率最多为392 h -1可以达到最佳催化剂的效果。此外，已经研究了各种溶剂的作用。所有使用的溶剂和形成的产物对底物转化率都有负面影响。对于两种常规反应方案，分别在45和90°C下仔细研究了反应的范围和限制。在超过20个示例中，过滤后的分离产率为90％。此外，我们提出了环己烯基天然存在的环状碳酸酯的首次有机催化合成，其分子结构由XRD确定。此外，我们证明了该反应甚至可以在数克范围内进行，并且可以通过原位FTIR光谱进行监测。

  DOI：

  10.1002/cctc.201402816
• 作为试剂：
  描述：

  丙烯酸丁酯 、 benzoic acid isopropenyl ester 在 Celite 、 2-hydroxy-N.N,N-tributylethanammonium bromide 、 palladium(II) bromide 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 16.0h， 以95%的产率得到(E)-3-(苯基)丙烯酸丁酯
  参考文献：
  名称：

  烯醇酯的脱羰癸基烯化：无盐且对环境友好的乙烯基芳烃。

  摘要：

  DOI：

  10.1002/anie.200352357

文献信息

• PROCESS FOR PRODUCING ETHYLENE GLYCOL CATALYZED BY IONIC LIQUID
  申请人：Zhang Suojiang

  公开号：US20130072727A1

  公开（公告）日：2013-03-21

  Disclosed is a process for producing ethylene glycol catalyzed by an ionic liquid, characterized in that the process includes the following three steps: (a) a carbonylation step of ethylene oxide and CO 2 catalyzed by an ionic liquid composite catalyst comprising a hydroxyl functionalized ionic liquid and an alkali metal salt under an aqueous condition to produce ethylene carbonate and ethylene glycol; (b) a hydrolysis step of reacting the reaction solution containing ethylene carbonate and the ionic liquid composite catalyst obtained in step (a) with water to produce ethylene glycol; (c) a purification step of dehydrating and refining ethylene glycol from the aqueous solution containing ethylene glycol and the catalyst produced in step (b). The present process has the following advantages: the catalyst has high activity, high suitability, and good stability, the reaction condition is wild, the conversion of ethylene oxide is high, the selectivity of ethylene glycol is high, and the process is simple.

  揭示了一种由离子液体催化生产乙二醇的过程，其特征在于该过程包括以下三个步骤：(a) 由含有羟基官能化离子液体和碱金属盐的离子液体复合催化剂在水相条件下催化乙烯氧化物和CO2的羰基化步骤，以产生碳酸乙烯酯和乙二醇；(b) 将步骤(a)中获得的含有碳酸乙烯和离子液体复合催化剂的反应溶液与水反应以产生乙二醇的水解步骤；(c) 从含有乙二醇和步骤(b)中产生的催化剂的水溶液中脱水和精制乙二醇的纯化步骤。该过程具有以下优点：催化剂活性高、适用性强、稳定性好，反应条件宽松，乙烯氧化物转化率高，乙二醇选择性高，过程简单。
• [EN] PROCESS FOR PREPARING CARBONATES BY ADDITION OF CO2 WITH AN EPOXIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CARBONATES PAR ADDITION DE CO2 AVEC UN ÉPOXYDE
  申请人：EVONIK ROEHM GMBH

  公开号：WO2019238548A1

  公开（公告）日：2019-12-19

  The invention relates to a process for preparing cyclic organic carbonates, characterized in that an epoxide is initially charged in the presence of CO2 and then a catalyst is added.

  该发明涉及一种制备环状有机碳酸酯的方法，其特点在于首先在CO2存在下加入环氧化物，然后再加入催化剂。
• [EN] COMPOSITE ABSORBENT AND USE THEREOF<br/>[FR] ABSORBANT COMPOSITE ET SON UTILISATION<br/>[ZH] 一种复合吸收剂及其用途
  申请人：INST PROCESS ENG CAS

  公开号：WO2021036238A1

  公开（公告）日：2021-03-04

  一种复合吸收剂及其用于环氧乙烷吸收转化耦合联产碳酸乙烯酯的方法。复合吸收剂包括离子液体和碳酸乙烯酯，离子液体为咪唑类、季铵类和季磷类离子液体。将上述复合吸收剂用来吸收环氧乙烷和二氧化碳，还用于环氧乙烷吸收转化耦合联产碳酸乙烯酯。
• Hydroxyl-functionalized ionic liquid: a novel efficient catalyst for chemical fixation of CO2 to cyclic carbonate
  作者：Jian Sun、Suojiang Zhang、Weiguo Cheng、Junyi Ren

  DOI：10.1016/j.tetlet.2008.04.022

  日期：2008.5

  A series of hydroxyl-functionalized ionic liquids (HFILs) were synthesized and characterized. They showed efficient reactivity and reusability toward the coupling of epoxide and CO2 without any additional co-catalyst and organic solvent. Highest activity and selectivity were achieved in the presence of 1-(2-hydroxyl-ethyl)-3-methylimidazolium bromide (HEMIMB) in comparison with other similar catalysts investigated. The relationship between the higher catalytic reactivity and OH-functional group was proposed. (C) 2008 Elsevier Ltd. All rights reserved.
• Soft Antimicrobial Agents:  Synthesis and Activity of Labile Environmentally Friendly Long Chain Quaternary Ammonium Compounds
  作者：Thorsteinn Thorsteinsson、Már Másson、Karl G. Kristinsson、Martha A. Hjálmarsdóttir、Hilmar Hilmarsson、Thorsteinn Loftsson

  DOI：10.1021/jm030829z

  日期：2003.9.1

  A series of soft quaternary ammonium antimicrobial agents, which are analogues to currently used quaternary ammonium preservatives such as cetyl pyridinium chloride and benzalkonium chloride, were synthesized. These soft analogues consist of long alkyl chain connected to a polar headgroup via chemically labile spacer group. They are characterized by facile nonenzymatic and enzymatic degradation to form their original nontoxic building blocks. However, their chemical stability has to be adequate in order for them to have antimicrobial effects. Stability studies and antibacterial and antiviral activity measurements revealed relationship between activity, lipophilicity, and stability. Their minimum inhibitory concentration (MIC) was as low as 1 mug/mL, and their viral reduction was in some cases greater than 6.7 log. The structure -activity studies demonstrate that the bioactive compounds (i.e., MIC for Gram-positive bacteria of < 10 umug/mL) have an alkyl chain length between 12 and 18 carbon atoms, with a polar headgroup preferably of a small quaternary ammonium group, and their acquired inactivation half-life must be greater than 3 h at 60 degreesC.