triptolide 14-tert-butyl carbonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: triptolide 14-tert-butyl carbonate
• 英文别名: Triptolide 14-tert-butyl carbonate, tert-Butyl (3bS,4aS,5aR,6R,6aS,7aS,7bS,8aS,8bS)-6a-iso-propyl-8b-methyl-1-oxo-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-6-yl carbonate；tert-butyl [(1S,2S,4S,5S,7S,8R,9R,11S,13S)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl] carbonate
• 化学式: C₂₅H₃₂O₈
• 分子量: 460.524
• InChiKey: LVHFSMVMWKBUOU-BWRTYORGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  99.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  雷公藤甲素 、 二碳酸二叔丁酯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以95.1%的产率得到triptolide 14-tert-butyl carbonate
  参考文献：
  名称：

  [EN] METHOD FOR TREATMENT OF INFLAMMATORY DISORDERS USING TRIPTOLIDE COMPOUNDS
  [FR] PROCEDE DE TRAITEMENT DE TROUBLES INFLAMMATOIRES AU MOYEN DE COMPOSES DE TRIPTOLIDE

  摘要：

  公开号：

  WO2006012204A3

文献信息

• Method for Treatment of Inflammatory Disorders Using Triptolide Compounds
  申请人：Fidler M. John

  公开号：US20070244080A1

  公开（公告）日：2007-10-18

  Inflammatory disorders, including obliterative airway disease, renal fibrosis, diabetic nephropathy, and liver fibrosis are treated with immunosuppressive triptolide compounds, in particular triptolide compounds effective to inhibit TGF-β production in a patient afflicted with such a disorder.

  炎症性疾病，包括闭塞性气道疾病、肾脏纤维化、糖尿病肾病和肝脏纤维化，可使用免疫抑制剂三尖杉酯化合物进行治疗，特别是在患有此类疾病的患者中，有效抑制TGF-β生成的三尖杉酯化合物。
• [EN] TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION<br/>[FR] DERIVES DE TRIPTOLIDE POUR LA MODULATION DE L'APOPTOSE ET DE L'IMMUNOSUPPRESSION
  申请人：——

  公开号：WO2003101951A3

  公开（公告）日：2004-05-06
• Triptolide Derivatives for Modulation of Apoptosis and Immunosuppression
  申请人：Dai Dongcheng

  公开号：US20090171103A1

  公开（公告）日：2009-07-02

  Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.
• TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION
  申请人：Dai Dongcheng

  公开号：US20110076293A1

  公开（公告）日：2011-03-31

  Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.
• INTRAVENOUS FORMULATIONS OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICANCER AGENTS
  申请人：PHARMAGENESIS, INC.

  公开号：US20160038454A1

  公开（公告）日：2016-02-11

  Intravenous formulations of triptolide and triptolide derivatives are disclosed for use in immunomodulation and anti-proliferative agents.